TY - JOUR
T1 - Shape analysis of hypertrophic and hypertensive heart disease using MRI-based 3D surface models of left ventricular geometry
AU - Ardekani, Siamak
AU - Jain, Saurabh
AU - Sanzi, Alianna
AU - Corona-Villalobos, Celia P.
AU - Abraham, Theodore P.
AU - Abraham, M. Roselle
AU - Zimmerman, Stefan L.
AU - Wu, Katherine C.
AU - Winslow, Raimond L.
AU - Miller, Michael I.
AU - Younes, Laurent
N1 - Publisher Copyright:
© 2015 Elsevier B.V.
PY - 2016/4/1
Y1 - 2016/4/1
N2 - The focus of this study was to develop advanced mathematical tools to construct high-resolution 3D models of left-ventricular (LV) geometry to evaluate focal geometric differences between patients with hypertrophic cardiomyopathy (HCM) and hypertensive heart disease (HHD) using cardiac magnetic resonance (MR) cross-sectional images. A limiting factor in 3D analysis of cardiac MR cross-sections is the low out-of-plane resolution of the acquired images. To overcome this problem, we have developed a mathematical framework to construct a population-based high-resolution 3D LV triangulated surface (template) in which an iterative matching algorithm maps a surface mesh of a normal heart to a set of cross-sectional contours that were extracted from short-axis cine cardiac MR images of patients who were diagnosed with either HCM or HHD. A statistical analysis was conducted on deformations that were estimated at each surface node to identify shape differences at end-diastole (ED), end-systole (ES), and motion-related shape variation from ED to ES. Some significant shape difference in radial thickness was detected at ES. Differences of LV 3D surface geometry were identified focally on the basal anterior septum wall. Further research is needed to relate these findings to the HCM morphological substrate and to design a classifier to discriminate among different etiologies of LV hypertrophy.
AB - The focus of this study was to develop advanced mathematical tools to construct high-resolution 3D models of left-ventricular (LV) geometry to evaluate focal geometric differences between patients with hypertrophic cardiomyopathy (HCM) and hypertensive heart disease (HHD) using cardiac magnetic resonance (MR) cross-sectional images. A limiting factor in 3D analysis of cardiac MR cross-sections is the low out-of-plane resolution of the acquired images. To overcome this problem, we have developed a mathematical framework to construct a population-based high-resolution 3D LV triangulated surface (template) in which an iterative matching algorithm maps a surface mesh of a normal heart to a set of cross-sectional contours that were extracted from short-axis cine cardiac MR images of patients who were diagnosed with either HCM or HHD. A statistical analysis was conducted on deformations that were estimated at each surface node to identify shape differences at end-diastole (ED), end-systole (ES), and motion-related shape variation from ED to ES. Some significant shape difference in radial thickness was detected at ES. Differences of LV 3D surface geometry were identified focally on the basal anterior septum wall. Further research is needed to relate these findings to the HCM morphological substrate and to design a classifier to discriminate among different etiologies of LV hypertrophy.
KW - 3D left-ventricular geometry
KW - Cardiac MRI
KW - Cardiomyopathy
KW - Surface-to-contour mapping
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U2 - 10.1016/j.media.2015.11.004
DO - 10.1016/j.media.2015.11.004
M3 - Article
C2 - 26766206
AN - SCOPUS:84952946959
SN - 1361-8415
VL - 29
SP - 12
EP - 23
JO - Medical image analysis
JF - Medical image analysis
ER -