@article{0def164db1494728a62c3b853ff33677,
title = "Shank, a novel family of postsynaptic density proteins that binds to the NMDA receptor/PSD-95/GKAP complex and cortactin",
abstract = "NMDA receptors are linked to intracellular cytoskeletal and signaling molecules via the PSD-95 protein complex. We report a novel family of postsynaptic density (PSD) proteins, termed Shank, that binds via its PDZ domain to the C terminus of PSD-95-associated protein GKAP. A ternary complex of Shank/GKAP/PSD95 assembles in heterologous cells and can be coimmunoprecipitated from rat brain. Synaptic localization of Shank in neurons is inhibited by a GKAP splice variant that lacks the Shank-binding C terminus. In addition to its PDZ domain, Shank contains a proline-rich region that binds to cortactin and a SAM domain that mediates multimerization. Shank may function as a scaffold protein in the PSD, potentially cross-linking NMDA receptor/PSD-95 complexes and coupling them to regulators of the actin cytoskeleton.",
author = "Scott Naisbitt and Kim Eunjoon and Tu, {Jian Cheng} and Bo Xiao and Carlo Sala and Juli Valtschanoff and Weinberg, {Richard J.} and Worley, {Paul F.} and Morgan Sheng",
note = "Funding Information: We thank Fu-Chia Yang for experimental help, J. Thomas Parsons (University of Virginia) for cortactin cDNA and antibodies, and Pann-Ghill Suh for Shank monoclonal antibodies. M. S. is an Assistant Investigator of the Howard Hughes Medical Institute. C. S. is a Harvard-Armenise Foundation Fellow (Department of Biological and Technical Reseach, Hospital San Raffaele, Scientific Institute, San Raffaele, Italy). This work was supported by the National Institutes of Health grants NS35050 (M. S.) and NS29879 (R. J. W.), the National Institute on Drug Abuse grants DA103009 and DA11742, the National Institute of Mental Health grant K02MH01152 (P. W.), and Korea Science and Engineering Foundation grant 981-0713-099-2 (E. K.). ",
year = "1999",
month = jul,
doi = "10.1016/S0896-6273(00)80809-0",
language = "English (US)",
volume = "23",
pages = "569--582",
journal = "Neuron",
issn = "0896-6273",
publisher = "Cell Press",
number = "3",
}