@article{66d9fb07c5f943499988feb18be46241,
title = "Sex-specific features of emphysema among current and former smokers with COPD",
abstract = "Recent studies suggest that males with chronic obstructive pulmonary disease (COPD) have more emphysema than females. It is not known if these differences persist across degrees of COPD severity. Our aim was to identify sex-specific differences in quantitative emphysema within COPD subgroups based on COPD severity. We included non-Hispanic white and African-American subjects from the COPDGene study with at least 10 pack-years of smoking and COPD Global Initiative for Chronic Obstructive Lung Disease (GOLD) spirometry grade II or greater. We examined sex-specific differences in log-transformed emphysema (log per cent low-attenuation area (%LAA)) by GOLD spirometry grade among subjects with early-onset COPD (<55 years old) and advanced emphysema (>25% emphysema). Compared with females, males had higher log %LAA: overall (1.97±1.4 versus 1.69±1.6, =0.32 (0.04), p=1.34×1014), and among non-Hispanic white (p=8.37×1014) and African-American subjects (p=0.002). Females with early-onset COPD, severe emphysema and GOLD grade IV COPD had similar emphysema as males, but markedly fewer pack-years smoking (early-onset, p=0.01; severe emphysema and GOLD grade IV, p<0.001). This study identifies subsets of female smokers with COPD who are particularly susceptible to parenchymal destruction.",
author = "Megan Hardin and Marilyn Foreman and Dransfield, {Mark T.} and Nadia Hansel and Han, {Mei Lan K.} and Cho, {Michael H.} and Bhatt, {Surya P.} and Joe Ramsdell and David Lynch and Curtis, {Jeffrey L.} and Silverman, {Edwin K.} and George Washko and Dawn DeMeo",
note = "Funding Information: R01 HL089438, K12 HL120004, R01 HL089856, R01 HL089897, P01 HL105339, 2013 Sheila J. Goodnight, MD, FCCP Clinical Research Grant in Women''s Lung Health. The COPDGene project described was supported by Award Number R01 HL089897 and Award Number R01 HL089856 from the National Heart, Lung, and Blood Institute. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Heart, Lung, and Blood Institute or the National Institutes of Health. The COPDGene project is also supported by the COPD Foundation through contributions made to an Industry Advisory Board comprised of AstraZeneca, Boehringer Ingelheim, Novartis, Pfizer, Siemens, Sunovion and GlaxoSmithKline. Funding information for this article has been deposited with FundRef. The authors would like to thank participants and field investigators in COPDGene for their willingness to contribute to medical research. COPDGene Investigators: Core Units. Administrative Core: James Crapo (Principal Investigator), Edwin Silverman (Principal Investigator), Barry Make, Elizabeth Regan. Genetic Analysis Core: Terri Beaty, Nan Laird, Christoph Lange, Michael Cho, Stephanie Santorico, John Hokanson, Dawn DeMeo, Nadia Hansel, Craig Hersh, Peter Castaldi, Merry-Lynn McDonald, Emily Wan, Megan Hardin, Jacqueline Hetmanski, Margaret Parker, Marilyn Foreman, Brian Hobbs, Robert Busch, Adel El-Bouiez, Peter Castaldi, Megan Hardin, Dandi Qiao, Elizabeth Regan, Eitan Halper-Stromberg, Ferdouse Begum, Sungho Won, Brittney Fredericksen, Sharon Lutz. Imaging Core: David A. Lynch, Harvey O. Coxson, MeiLan K. Han, Eric A. Hoffman, Stephen Humphries, Francine L. Jacobson, Philip F. Judy, Ella A. Kazerooni, John D. Newell Jr, Elizabeth Regan, James C. Ross, Raul San Jose Estepar, Berend C. Stoel, Juerg Tschirren, Eva van Rikxoort, Bram van Ginneken, George Washko, Carla G. Wilson, Mustafa Al Qaisi, Teresa Gray, Alex Kluiber, Tanya Mann, Jered Sieren, Douglas Stinson, Joyce Schroeder, Edwin Van Beek. PFT QA Core, Salt Lake City, UT, USA: Robert Jensen. Data Coordinating Center and Biostatistics, National Jewish Health, Denver, CO, USA: Douglas Everett, Anna Faino, Matt Strand, Carla Wilson. Epidemiology Core, University of Colorado Anschutz Medical Campus, Aurora, CO, USA: John E. Hokanson, Jennifer Black-Shinn, Gregory Kinney, Sharon Lutz, Katherine Pratte. COPDGene Investigators: Clinical Centers. Ann Arbor VA, MI, USA: Jeffrey Curtis, Carlos Martinez, Perry G. Pernicano. Baylor College of Medicine, Houston, TX, USA: Nicola Hanania, Philip Alapat, Venkata Bandi, Mustafa Atik, Aladin Boriek, Kalpatha Guntupalli, Elizabeth Guy, Amit Parulekar, Arun Nachiappan. Brigham and Women''s Hospital, Boston, MA, USA: Dawn DeMeo, Craig Hersh, George Washko, Francine Jacobson. Columbia University, New York, NY, USA: R. Graham Barr, Byron Thomashow, John Austin, Belinda D''Souza, Gregory D.N. Pearson, Anna Rozenshtein. Duke University Medical Center, Durham, NC, USA: Neil MacIntyre Jr, Lacey Washington, H. Page McAdams. Health Partners Research Foundation, Minneapolis, MN, USA: Charlene McEvoy, Joseph Tashjian. Johns Hopkins University, Baltimore, MD, USA: Robert Wise, Nadia Hansel, Robert Brown, Karen Horton, Nirupama Putcha. Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Los Angeles, CA, USA: Richard Casaburi, Alessandra Adami, Janos Porszasz, Hans Fischer, Matthew Budoff, Dan Cannon, Harry Rossiter. Michael E. DeBakey VAMC, Houston, TX, USA: Amir Sharafkhaneh, Charlie Lan. Minneapolis VA, MN, USA: Christine Wendt, Brian Bell. Morehouse School of Medicine, Atlanta, GA, USA: Marilyn Foreman, Gloria Westney, Eugene Berkowitz. National Jewish Health, Denver, CO, USA: Russell Bowler, David Lynch. Reliant Medical Group, Worcester, MA, USA: Richard Rosiello, David Pace. Temple University, Philadelphia, PA, USA: Gerard Criner, David Ciccolella, Francis Cordova, Chandra Dass, Robert D''Alonzo, Parag Desai, Michael Jacobs, Steven Kelsen, Victor Kim, A. James Mamary, Nathaniel Marchetti, Aditti Satti, Kartik Shenoy, Robert M. Steiner, Alex Swift, Irene Swift, Gloria Vega-Sanchez. University of Alabama, Birmingham, AL, USA: Mark Dransfield, William Bailey, J. Michael Wells, Surya Bhatt, Hrudaya Nath. University of California, San Diego, CA, USA: Joe Ramsdell, Paul Friedman, Xavier Soler, Andrew Yen. University of Iowa, Iowa City, IA, USA: Alejandro Cornellas, John Newell Jr, Brad Thompson. University of Michigan, Ann Arbor, MI, USA: MeiLan Han, Ella Kazerooni, Fernando Martinez. University of Minnesota, Minneapolis, MN, USA: Joanne Billings, Tadashi Allen. University of Pittsburgh, Pittsburgh, PA, USA: Frank Sciurba, Divay Chandra, Joel Weissfeld, Carl Fuhrman, Jessica Bon. University of Texas Health Science Center at San Antonio, San Antonio, TX, USA: Antonio Anzueto, Sandra Adams, Diego Maselli-Caceres, Mario E. Ruiz. Publisher Copyright: {\textcopyright} ERS 2016.",
year = "2016",
month = jan,
day = "1",
doi = "10.1183/13993003.00996-2015",
language = "English (US)",
volume = "47",
pages = "104--112",
journal = "European Respiratory Journal",
issn = "0903-1936",
publisher = "European Respiratory Society",
number = "1",
}