TY - JOUR
T1 - Sex Hormones, Sleep, and Memory
T2 - Interrelationships Across the Adult Female Lifespan
AU - Harrington, Yasmin A.
AU - Parisi, Jeanine M.
AU - Duan, Daisy
AU - Rojo-Wissar, Darlynn M.
AU - Holingue, Calliope
AU - Spira, Adam P.
N1 - Funding Information:
DR-W is supported by the Eunice Kennedy Shriver National Institute of Child Health and Human Development’s Training Program in Childhood Stress, Trauma, & Resilience (T32HD101392; PIs: Stroud, Laura & Tyrka, Audrey). DD is supported by National Institutes of Health 5T32HL110952. AS is supported in part by AG050507, AG052445, AG049872, AG040282, and AG050745 from the National Institute on Aging.
Publisher Copyright:
Copyright © 2022 Harrington, Parisi, Duan, Rojo-Wissar, Holingue and Spira.
PY - 2022/7/14
Y1 - 2022/7/14
N2 - As the population of older adults grows, so will the prevalence of aging-related conditions, including memory impairments and sleep disturbances, both of which are more common among women. Compared to older men, older women are up to twice as likely to experience sleep disturbances and are at a higher risk of cognitive decline and Alzheimer’s disease and related dementias (ADRD). These sex differences may be attributed in part to fluctuations in levels of female sex hormones (i.e., estrogen and progesterone) that occur across the adult female lifespan. Though women tend to experience the most significant sleep and memory problems during the peri-menopausal period, changes in memory and sleep have also been observed across the menstrual cycle and during pregnancy. Here, we review current knowledge on the interrelationships among female sex hormones, sleep, and memory across the female lifespan, propose possible mediating and moderating mechanisms linking these variables and describe implications for ADRD risk in later life.
AB - As the population of older adults grows, so will the prevalence of aging-related conditions, including memory impairments and sleep disturbances, both of which are more common among women. Compared to older men, older women are up to twice as likely to experience sleep disturbances and are at a higher risk of cognitive decline and Alzheimer’s disease and related dementias (ADRD). These sex differences may be attributed in part to fluctuations in levels of female sex hormones (i.e., estrogen and progesterone) that occur across the adult female lifespan. Though women tend to experience the most significant sleep and memory problems during the peri-menopausal period, changes in memory and sleep have also been observed across the menstrual cycle and during pregnancy. Here, we review current knowledge on the interrelationships among female sex hormones, sleep, and memory across the female lifespan, propose possible mediating and moderating mechanisms linking these variables and describe implications for ADRD risk in later life.
KW - Alzheimer’s disease
KW - adults
KW - dementia
KW - hormones
KW - memory
KW - sex
KW - sleep
UR - http://www.scopus.com/inward/record.url?scp=85135079619&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85135079619&partnerID=8YFLogxK
U2 - 10.3389/fnagi.2022.800278
DO - 10.3389/fnagi.2022.800278
M3 - Review article
C2 - 35912083
AN - SCOPUS:85135079619
SN - 1663-4365
VL - 14
JO - Frontiers in Aging Neuroscience
JF - Frontiers in Aging Neuroscience
M1 - 800278
ER -