Sex differences in risk of Alzheimer's disease in adults with Down syndrome

Florence Lai; Pooja G. Mhatre; Yuchen Yang; Mei Cheng Wang; Nicole Schupf; H. Diana Rosas

doi:10.1002/dad2.12084

Sex differences in risk of Alzheimer's disease in adults with Down syndrome

Florence Lai, Pooja G. Mhatre, Yuchen Yang, Mei Cheng Wang, Nicole Schupf, H. Diana Rosas

Research output: Contribution to journal › Article › peer-review

Abstract

Introduction: Adults with Down syndrome (DS) older than 40 have Alzheimer's disease (AD) neuropathology and high risk for dementia, but little is known about the relationship of sex to AD risk in this population. Methods: Using nonparametric methods and Cox proportional hazards models we analyzed differences in incidence of dementia, by sex, presence of an apolipoprotein E (APOE) ε4 or ε2 allele, and dementia duration and decline in 246 adults over 40 with DS. Results: There was no significant sex difference in risk of AD or rate of cognitive decline. APOE ε4 allele significantly increased risk of AD irrespective of sex. No significant interactions were found between sex and APOE status on AD risk. Among those who died, dementia duration was significantly longer in women. Discussion: This study showed no effect of sex nor interaction between sex and APOE for risk of AD in adults with DS; however, women had longer dementia duration.

Original language	English (US)
Article number	e12084
Journal	Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
Volume	12
Issue number	1
DOIs	https://doi.org/10.1002/dad2.12084
State	Published - 2020
Externally published	Yes

Keywords

Alzheimer's disease
Down syndrome
apolipoprotein ε2 allele
apolipoprotein ε4 allele
cognitive decline
dementia duration
sex differences in Alzheimer's disease

ASJC Scopus subject areas

Clinical Neurology
Psychiatry and Mental health

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10.1002/dad2.12084

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@article{2022bd600f8145c1943724a245ed98c5,

title = "Sex differences in risk of Alzheimer's disease in adults with Down syndrome",

abstract = "Introduction: Adults with Down syndrome (DS) older than 40 have Alzheimer's disease (AD) neuropathology and high risk for dementia, but little is known about the relationship of sex to AD risk in this population. Methods: Using nonparametric methods and Cox proportional hazards models we analyzed differences in incidence of dementia, by sex, presence of an apolipoprotein E (APOE) ε4 or ε2 allele, and dementia duration and decline in 246 adults over 40 with DS. Results: There was no significant sex difference in risk of AD or rate of cognitive decline. APOE ε4 allele significantly increased risk of AD irrespective of sex. No significant interactions were found between sex and APOE status on AD risk. Among those who died, dementia duration was significantly longer in women. Discussion: This study showed no effect of sex nor interaction between sex and APOE for risk of AD in adults with DS; however, women had longer dementia duration.",

keywords = "Alzheimer's disease, Down syndrome, apolipoprotein ε2 allele, apolipoprotein ε4 allele, cognitive decline, dementia duration, sex differences in Alzheimer's disease",

author = "Florence Lai and Mhatre, {Pooja G.} and Yuchen Yang and Wang, {Mei Cheng} and Nicole Schupf and Rosas, {H. Diana}",

note = "Funding Information: Support for this work was funded in part through the Alzheimer Disease in Down Syndrome study (NIH U01 AG051412). Publisher Copyright: {\textcopyright} 2020 The Authors. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring published by Wiley Periodicals, Inc. on behalf of the Alzheimer's Association.",

year = "2020",

doi = "10.1002/dad2.12084",

language = "English (US)",

volume = "12",

journal = "Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring",

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TY - JOUR

T1 - Sex differences in risk of Alzheimer's disease in adults with Down syndrome

AU - Lai, Florence

AU - Mhatre, Pooja G.

AU - Yang, Yuchen

AU - Wang, Mei Cheng

AU - Schupf, Nicole

AU - Rosas, H. Diana

N1 - Funding Information: Support for this work was funded in part through the Alzheimer Disease in Down Syndrome study (NIH U01 AG051412). Publisher Copyright: © 2020 The Authors. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring published by Wiley Periodicals, Inc. on behalf of the Alzheimer's Association.

PY - 2020

Y1 - 2020

N2 - Introduction: Adults with Down syndrome (DS) older than 40 have Alzheimer's disease (AD) neuropathology and high risk for dementia, but little is known about the relationship of sex to AD risk in this population. Methods: Using nonparametric methods and Cox proportional hazards models we analyzed differences in incidence of dementia, by sex, presence of an apolipoprotein E (APOE) ε4 or ε2 allele, and dementia duration and decline in 246 adults over 40 with DS. Results: There was no significant sex difference in risk of AD or rate of cognitive decline. APOE ε4 allele significantly increased risk of AD irrespective of sex. No significant interactions were found between sex and APOE status on AD risk. Among those who died, dementia duration was significantly longer in women. Discussion: This study showed no effect of sex nor interaction between sex and APOE for risk of AD in adults with DS; however, women had longer dementia duration.

AB - Introduction: Adults with Down syndrome (DS) older than 40 have Alzheimer's disease (AD) neuropathology and high risk for dementia, but little is known about the relationship of sex to AD risk in this population. Methods: Using nonparametric methods and Cox proportional hazards models we analyzed differences in incidence of dementia, by sex, presence of an apolipoprotein E (APOE) ε4 or ε2 allele, and dementia duration and decline in 246 adults over 40 with DS. Results: There was no significant sex difference in risk of AD or rate of cognitive decline. APOE ε4 allele significantly increased risk of AD irrespective of sex. No significant interactions were found between sex and APOE status on AD risk. Among those who died, dementia duration was significantly longer in women. Discussion: This study showed no effect of sex nor interaction between sex and APOE for risk of AD in adults with DS; however, women had longer dementia duration.

KW - Alzheimer's disease

KW - Down syndrome

KW - apolipoprotein ε2 allele

KW - apolipoprotein ε4 allele

KW - cognitive decline

KW - dementia duration

KW - sex differences in Alzheimer's disease

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JO - Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring

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ER -

Sex differences in risk of Alzheimer's disease in adults with Down syndrome

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Keywords

ASJC Scopus subject areas

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