TY - JOUR
T1 - Sex differences in HIV infection
T2 - Mystique versus machismo
AU - Scully, Eileen P.
N1 - Funding Information:
Dr. Scully is supported by the NIH/NIAID: K08AI116344 and has received support for this work from amfAR through an ARCHE grant 108842-55-RGRL.
Publisher Copyright:
© Pathogens and Immunity 2018.
PY - 2018
Y1 - 2018
N2 - Biological sex is a determinant of both susceptibility to and pathogenesis of multiple infections, including HIV. These differences have effects on the spectrum of HIV disease from acquisition to eradication, with diverse mechanisms including distinct chromosomal complements, variation in microbiota composition, hormonal effects on transcriptional profiles, and expression of different immunoregulatory elements. With a comparative biology approach, these sex differences can be used to highlight protective and detrimental immune activation pathways, to identify strategies for effective prevention, treatment, and curative interventions.
AB - Biological sex is a determinant of both susceptibility to and pathogenesis of multiple infections, including HIV. These differences have effects on the spectrum of HIV disease from acquisition to eradication, with diverse mechanisms including distinct chromosomal complements, variation in microbiota composition, hormonal effects on transcriptional profiles, and expression of different immunoregulatory elements. With a comparative biology approach, these sex differences can be used to highlight protective and detrimental immune activation pathways, to identify strategies for effective prevention, treatment, and curative interventions.
KW - Gender
KW - HIV
KW - Immune response
KW - Sexually transmitted diseases
UR - http://www.scopus.com/inward/record.url?scp=85083326681&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85083326681&partnerID=8YFLogxK
U2 - 10.20411/pai.v3i1.238
DO - 10.20411/pai.v3i1.238
M3 - Review article
AN - SCOPUS:85083326681
SN - 2469-2964
VL - 3
SP - 82
EP - 113
JO - Pathogens and Immunity
JF - Pathogens and Immunity
IS - 1
ER -