Sex differences in HIV infection: Mystique versus machismo

Research output: Contribution to journalReview articlepeer-review


Biological sex is a determinant of both susceptibility to and pathogenesis of multiple infections, including HIV. These differences have effects on the spectrum of HIV disease from acquisition to eradication, with diverse mechanisms including distinct chromosomal complements, variation in microbiota composition, hormonal effects on transcriptional profiles, and expression of different immunoregulatory elements. With a comparative biology approach, these sex differences can be used to highlight protective and detrimental immune activation pathways, to identify strategies for effective prevention, treatment, and curative interventions.

Original languageEnglish (US)
Pages (from-to)82-113
Number of pages32
JournalPathogens and Immunity
Issue number1
StatePublished - 2018


  • Gender
  • HIV
  • Immune response
  • Sexually transmitted diseases

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Molecular Biology
  • Microbiology (medical)
  • Infectious Diseases


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