Sex differences in a murine model of Sjögren's syndrome

Daniela Iháková; Monica V. Talor; Jobert G. Barin; G. Christian Baldeviano; Delisa Fairweather; Noel R. Rose; C. Lynne Burek

doi:10.1111/j.1749-6632.2009.04760.x

Sex differences in a murine model of Sjögren's syndrome

Daniela Iháková, Monica V. Talor, Jobert G. Barin, G. Christian Baldeviano, Delisa Fairweather, Noel R. Rose, C. Lynne Burek

School of Medicine

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

20 Scopus citations

Abstract

Sex differences in a NOD.H2^h4 murine model of Sjögren's syndrome were analyzed. Compared to males, female NOD.H2^h4 mice have increased severity of sialoadenitis and have a significantly increased percentage of CD4⁺ T cells in salivary gland infiltrates. CD4 ⁺ T cells in female infiltrates produce more Th2 and Th17 cytokines than in males, while males have greater Th1 responses. Females also have enhanced B cell responses, with higher levels of SSA and SSB serum antibodies, and B cell activation factor F (BAFF). Thus, sex has a strong impact on the severity of murine Sjögren's syndrome by affecting the immune mechanisms driving the autoimmune inflammation.

Original language	English (US)
Title of host publication	Contemporary Challenges in Autoimmunity
Pages	378-383
Number of pages	6
Volume	1173
DOIs	https://doi.org/10.1111/j.1749-6632.2009.04760.x
State	Published - Sep 2009

Keywords

BAFF
IL-17
SSA and SSB antibodies
Salivary gland
Sex differences
Sjögren's syndrome
T cells
Th17

ASJC Scopus subject areas

General Neuroscience
General Biochemistry, Genetics and Molecular Biology
History and Philosophy of Science

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10.1111/j.1749-6632.2009.04760.x

Cite this

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title = "Sex differences in a murine model of Sj{\"o}gren's syndrome",

abstract = "Sex differences in a NOD.H2h4 murine model of Sj{\"o}gren's syndrome were analyzed. Compared to males, female NOD.H2h4 mice have increased severity of sialoadenitis and have a significantly increased percentage of CD4+ T cells in salivary gland infiltrates. CD4 + T cells in female infiltrates produce more Th2 and Th17 cytokines than in males, while males have greater Th1 responses. Females also have enhanced B cell responses, with higher levels of SSA and SSB serum antibodies, and B cell activation factor F (BAFF). Thus, sex has a strong impact on the severity of murine Sj{\"o}gren's syndrome by affecting the immune mechanisms driving the autoimmune inflammation.",

keywords = "BAFF, IL-17, SSA and SSB antibodies, Salivary gland, Sex differences, Sj{\"o}gren's syndrome, T cells, Th17",

author = "Daniela Ih{\'a}kov{\'a} and Talor, {Monica V.} and Barin, {Jobert G.} and Baldeviano, {G. Christian} and Delisa Fairweather and Rose, {Noel R.} and Burek, {C. Lynne}",

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AU - Iháková, Daniela

AU - Talor, Monica V.

AU - Barin, Jobert G.

AU - Baldeviano, G. Christian

AU - Fairweather, Delisa

AU - Rose, Noel R.

AU - Burek, C. Lynne

PY - 2009/9

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N2 - Sex differences in a NOD.H2h4 murine model of Sjögren's syndrome were analyzed. Compared to males, female NOD.H2h4 mice have increased severity of sialoadenitis and have a significantly increased percentage of CD4+ T cells in salivary gland infiltrates. CD4 + T cells in female infiltrates produce more Th2 and Th17 cytokines than in males, while males have greater Th1 responses. Females also have enhanced B cell responses, with higher levels of SSA and SSB serum antibodies, and B cell activation factor F (BAFF). Thus, sex has a strong impact on the severity of murine Sjögren's syndrome by affecting the immune mechanisms driving the autoimmune inflammation.

AB - Sex differences in a NOD.H2h4 murine model of Sjögren's syndrome were analyzed. Compared to males, female NOD.H2h4 mice have increased severity of sialoadenitis and have a significantly increased percentage of CD4+ T cells in salivary gland infiltrates. CD4 + T cells in female infiltrates produce more Th2 and Th17 cytokines than in males, while males have greater Th1 responses. Females also have enhanced B cell responses, with higher levels of SSA and SSB serum antibodies, and B cell activation factor F (BAFF). Thus, sex has a strong impact on the severity of murine Sjögren's syndrome by affecting the immune mechanisms driving the autoimmune inflammation.

KW - BAFF

KW - IL-17

KW - SSA and SSB antibodies

KW - Salivary gland

KW - Sex differences

KW - Sjögren's syndrome

KW - T cells

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Sex differences in a murine model of Sjögren's syndrome

Abstract

Keywords

ASJC Scopus subject areas

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