TY - JOUR
T1 - Sex-based differences in T lymphocyte responses in HIV-1-seropositive individuals
AU - Sterling, Timothy R.
AU - Pisell-Noland, Tracy
AU - Perez, John L.
AU - Astemborski, Jacquie
AU - McGriff, Joelle R.
AU - Nutting, Lisa
AU - Hoover, Donald R.
AU - Vlahov, David
AU - Bollinger, Robert C.
N1 - Funding Information:
Received 16 June 2004; accepted 1 October 2004; electronically published 7 February 2005. Financial support: National Institute on Drug Abuse (grants RO-1 DA04334 and RO-1 DA08009); National Institute of Allergy and Infectious Diseases (grant K23 AI01654). Reprints or correspondence: Dr. Timothy R. Sterling, Div. of Infectious Diseases, Vanderbilt University Medical Center, A4103 Medical Center North, 1161 21st Ave. S., Nashville, TN 37232 (timothy.sterling@vanderbilt.edu).
PY - 2005/3/15
Y1 - 2005/3/15
N2 - Sex-based differences in the levels of human immunodeficiency virus 1 (HIV-1) RNA in plasma could be associated with differences in the strength of HIV-1-specific CD8+ T cell responses. CD8+ effector responses in 18 men and 15 women were measured 0-2 years (time A) and 5-7 years (time B) after seroconversion. CD8+ effector responses were seen in 7 (39%) of 18 men and 2 (13%) of 15 women at time A (P = .13) and in 12 (67%) of 18 men and 10 (67%) of 15 women at time B (P = .99). At time B, the strength of CD8+ effector responses correlated with the number of CD4+ lymphocytes in women (p = -0.68; P = .005) but not in men (p = -0.14; P = .58). The level of HIV-1 RNA was not associated with the strength of CD8+ effector responses according to sex, but there was a sex-based difference in the correlation between the strength of CD8+ effector response and the number of CD4+ lymphocytes.
AB - Sex-based differences in the levels of human immunodeficiency virus 1 (HIV-1) RNA in plasma could be associated with differences in the strength of HIV-1-specific CD8+ T cell responses. CD8+ effector responses in 18 men and 15 women were measured 0-2 years (time A) and 5-7 years (time B) after seroconversion. CD8+ effector responses were seen in 7 (39%) of 18 men and 2 (13%) of 15 women at time A (P = .13) and in 12 (67%) of 18 men and 10 (67%) of 15 women at time B (P = .99). At time B, the strength of CD8+ effector responses correlated with the number of CD4+ lymphocytes in women (p = -0.68; P = .005) but not in men (p = -0.14; P = .58). The level of HIV-1 RNA was not associated with the strength of CD8+ effector responses according to sex, but there was a sex-based difference in the correlation between the strength of CD8+ effector response and the number of CD4+ lymphocytes.
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U2 - 10.1086/427827
DO - 10.1086/427827
M3 - Article
C2 - 15717262
AN - SCOPUS:14844336896
SN - 0022-1899
VL - 191
SP - 881
EP - 885
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 6
ER -