Severity of hypoxemia and effect of high-frequency oscillatory ventilation in acute respiratory distress syndrome

Maureen O. Meade, Duncan Young, Steven Hanna, Qi Zhou, Thomas E. Bachman, Casper Bollen, Arthur S. Slutsky, Sarah E. Lamb, Neill K.J. Adhikari, Spyros D. Mentzelopoulos, Deborah J. Cook, Sachin Sud, Roy G. Brower, B. Taylor Thompson, Sanjoy Shah, Alex Stenzler, Gordon Guyatt, Niall D. Ferguson

Research output: Contribution to journalArticlepeer-review

41 Scopus citations


Rationale: High-frequency oscillatory ventilation (HFOV) is theoretically beneficial for lung protection, but the results of clinical trials are inconsistent, with study-level meta-analyses suggesting no significant effect on mortality. Objectives: The aim of this individual patient data meta-analysis was to identify acute respiratory distress syndrome (ARDS) patient subgroups with differential outcomes from HFOV. Methods: After a comprehensive search for trials, two reviewers independently identified randomized trials comparing HFOV with conventional ventilation for adults with ARDS. Prespecified effect modifiers were tested using multivariable hierarchical logistic regression models, adjusting for important prognostic factors and clustering effects. Measurements and Main Results: Data from 1,552 patients in four trials were analyzed, applying uniform definitions for study variables and outcomes. Patients had a mean baseline PaO2/FIO2 of 114 - 39 mm Hg; 40% had severe ARDS (PaO2/FIO2 ,100 mm Hg). Mortality at 30 days was 321 of 785 (40.9%) for HFOV patients versus 288 of 767 (37.6%) for control subjects (adjusted odds ratio, 1.17; 95% confidence interval, 0.94–1.46; P = 0.16). This treatment effect varied, however, depending on baseline severity of hypoxemia (P = 0.0003), with harm increasing with PaO2/FIO2 among patients with mild-moderate ARDS, and the possibility of decreased mortality in patients with very severe ARDS. Compliance and body mass index did not modify the treatment effect. HFOV increased barotrauma risk compared with conventional ventilation (adjusted odds ratio, 1.75; 95% confidence interval, 1.04–2.96; P = 0.04). Conclusions: HFOV increases mortality for most patients with ARDS but may improve survival among patients with severe hypoxemia on conventional mechanical ventilation.

Original languageEnglish (US)
Pages (from-to)727-733
Number of pages7
JournalAmerican journal of respiratory and critical care medicine
Issue number6
StatePublished - Sep 15 2017


  • Acute respiratory distress syndrome
  • High-frequency oscillatory ventilation
  • Mechanical ventilation

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine


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