Abstract
We report on a 5-year-old girl with an unusually severe course of tick-borne encephalitis following passive immunization with specific hyperimmune globulin after a tick bite in an endemic area. Serial investigations of the CSF revealed intrathecal production of specific antibodies paralleled by increasing numbers of B-cells after initial T-cell pleocytosis. Focal central lesions were evident on MRI. Conclusion: The severity of the presented case questions the benefit of passive immunization and rather justifies consideration of vaccine recommendation to residents and travellers to areas endemic for tickborne encephalitis virus.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 775-779 |
| Number of pages | 5 |
| Journal | European Journal of Pediatrics |
| Volume | 155 |
| Issue number | 9 |
| DOIs | |
| State | Published - 1996 |
| Externally published | Yes |
Keywords
- Cerebrospinal fluid
- Neuroimaging
- Passive immunization
- Sequalae
- Tick-borne encephalitis
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health