We report on a 5-year-old girl with an unusually severe course of tick-borne encephalitis following passive immunization with specific hyperimmune globulin after a tick bite in an endemic area. Serial investigations of the CSF revealed intrathecal production of specific antibodies paralleled by increasing numbers of B-cells after initial T-cell pleocytosis. Focal central lesions were evident on MRI. Conclusion: The severity of the presented case questions the benefit of passive immunization and rather justifies consideration of vaccine recommendation to residents and travellers to areas endemic for tickborne encephalitis virus.
- Cerebrospinal fluid
- Passive immunization
- Tick-borne encephalitis
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health