Severe tick-borne encephalitis following passive immunization

K. Waldvogel, W. Bossart, T. Huisman, E. Boltshauser, D. Nadal

Research output: Contribution to journalArticlepeer-review

50 Scopus citations


We report on a 5-year-old girl with an unusually severe course of tick-borne encephalitis following passive immunization with specific hyperimmune globulin after a tick bite in an endemic area. Serial investigations of the CSF revealed intrathecal production of specific antibodies paralleled by increasing numbers of B-cells after initial T-cell pleocytosis. Focal central lesions were evident on MRI. Conclusion: The severity of the presented case questions the benefit of passive immunization and rather justifies consideration of vaccine recommendation to residents and travellers to areas endemic for tickborne encephalitis virus.

Original languageEnglish (US)
Pages (from-to)775-779
Number of pages5
JournalEuropean Journal of Pediatrics
Issue number9
StatePublished - 1996
Externally publishedYes


  • Cerebrospinal fluid
  • Neuroimaging
  • Passive immunization
  • Sequalae
  • Tick-borne encephalitis

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


Dive into the research topics of 'Severe tick-borne encephalitis following passive immunization'. Together they form a unique fingerprint.

Cite this