TY - JOUR
T1 - Severe respiratory syncytial virus disease in Alaska native children
AU - Karron, Ruth A.
AU - Singleton, Rosalyn J.
AU - Bulkow, Lisa
AU - Parkinson, Alan
AU - Kruse, Donn
AU - DeSmet, Irma
AU - Indorf, Carol
AU - Petersen, Kenneth M.
AU - Leombruno, Donna
AU - Hurlburt, Debra
AU - Santosham, Mathuram
AU - Harrison, Lee H.
PY - 1999
Y1 - 1999
N2 - Hospitalization rates for respiratory syncytial virus (RSV) infection range from 1 to 20/1000 infants. To determine the rate and severity of RSV infections requiring hospitalization for infants in the Yukon-Kuskokwim (YK) Delta of Alaska, a 3-year prospective surveillance study was conducted. The annual rate of RSV hospitalization for YK Delta infants <1 year of age was 53-249/1000. RSV infection was the most frequent cause of infant hospitalization. RSV disease severity did not differ among non-high-risk infants in the YK Delta and at Johns Hopkins Hospital (JHH). On average, 1/125 infants born in the YK Delta required mechanical ventilation for RSV infection. During the peak season, ~$1034/child <3 years of age was spent on RSV hospitalization in the YK Delta. In YK Delta infants ≤6 months old, RSV microneutralizing antibody liters <1200 were associated with severe disease (odds ratio = 6.2, P = .03). In the YK Delta and at JHH, newborns may be at greater risk for severe RSV illness than previously thought.
AB - Hospitalization rates for respiratory syncytial virus (RSV) infection range from 1 to 20/1000 infants. To determine the rate and severity of RSV infections requiring hospitalization for infants in the Yukon-Kuskokwim (YK) Delta of Alaska, a 3-year prospective surveillance study was conducted. The annual rate of RSV hospitalization for YK Delta infants <1 year of age was 53-249/1000. RSV infection was the most frequent cause of infant hospitalization. RSV disease severity did not differ among non-high-risk infants in the YK Delta and at Johns Hopkins Hospital (JHH). On average, 1/125 infants born in the YK Delta required mechanical ventilation for RSV infection. During the peak season, ~$1034/child <3 years of age was spent on RSV hospitalization in the YK Delta. In YK Delta infants ≤6 months old, RSV microneutralizing antibody liters <1200 were associated with severe disease (odds ratio = 6.2, P = .03). In the YK Delta and at JHH, newborns may be at greater risk for severe RSV illness than previously thought.
UR - http://www.scopus.com/inward/record.url?scp=0033015902&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0033015902&partnerID=8YFLogxK
U2 - 10.1086/314841
DO - 10.1086/314841
M3 - Article
C2 - 10353859
AN - SCOPUS:0033015902
SN - 0022-1899
VL - 180
SP - 41
EP - 49
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 1
ER -