TY - JOUR
T1 - Severe osteopenia and osteoporosis, sarcopenia, and frailty status in community-dwelling older women
T2 - Results from the Women's Health and Aging Study (WHAS) II
AU - Frisoli, Alberto
AU - Chaves, Paulo Henrique
AU - Ingham, Sheila Jean Mc Neill
AU - Fried, Linda P.
PY - 2011/4/1
Y1 - 2011/4/1
N2 - Objectives: The goal of this study was to examine the associations between severe osteopenia and osteoporosis and/or sarcopenia on frailty status, a major geriatric syndrome in community-dwelling older women. Design: Cross-sectional analysis. Setting: Women's Health and Aging Studies II (WHAS-II), Baltimore, Maryland. Participants and measurements: The analytic sample for this study included 250 women aged 76-86years old who underwent DXA evaluation at round 4. Frailty was determined using validated screening criteria. Severe osteopenia was defined as BMD between -2.0 SD and -2.49 SD and osteoporosis as BMD less than -2.5 SD (lumbar spine and/or proximal femur). Sarcopenia was determined by the appendicular lean mass by height2 (aLM/ht2 method) and considered present when the value was less then -2 SD compared to young women. Results: Mean age of study subjects was 79.6 (± 2.7) years. Overall prevalence of frailty was 6.8% (n = 17). Severe osteopenia/osteoporosis occurred in 42.1% (n = 7) in the frail group, 28% (n = 33) in the pre frail group and 25.2% in the robust group. Sarcopenia was present in 52.9% (n = 9) in the frail group, 42% (n = 50) in the pre frail and 41.2% (n = 47) in the robust group. Almost sixteen percent (n = 39) had severe osteopenia/osteoporosis concomitant to sarcopenia. In an adjusted logistic regression model, severe osteopenia/osteoporosis (OR: 2.1; 95% CI: 0.68-6.6, p = 0.196) and sarcopenia (OR: 3.1; 95% CI: 0.88-11.1; p = 0.077) were individually associated with frailty, though not statistically significant. On the other hand, the likelihood of being frail was substantially higher in the presence of these two syndromes (OR: 6.4; 95% CI: 1.1-36.8, p=0.037). Conclusion: These findings suggest a concomitant impact of severe osteopenia/osteoporosis plus sarcopenia in regard to frailty status in a sample of oldest old women living in the community.
AB - Objectives: The goal of this study was to examine the associations between severe osteopenia and osteoporosis and/or sarcopenia on frailty status, a major geriatric syndrome in community-dwelling older women. Design: Cross-sectional analysis. Setting: Women's Health and Aging Studies II (WHAS-II), Baltimore, Maryland. Participants and measurements: The analytic sample for this study included 250 women aged 76-86years old who underwent DXA evaluation at round 4. Frailty was determined using validated screening criteria. Severe osteopenia was defined as BMD between -2.0 SD and -2.49 SD and osteoporosis as BMD less than -2.5 SD (lumbar spine and/or proximal femur). Sarcopenia was determined by the appendicular lean mass by height2 (aLM/ht2 method) and considered present when the value was less then -2 SD compared to young women. Results: Mean age of study subjects was 79.6 (± 2.7) years. Overall prevalence of frailty was 6.8% (n = 17). Severe osteopenia/osteoporosis occurred in 42.1% (n = 7) in the frail group, 28% (n = 33) in the pre frail group and 25.2% in the robust group. Sarcopenia was present in 52.9% (n = 9) in the frail group, 42% (n = 50) in the pre frail and 41.2% (n = 47) in the robust group. Almost sixteen percent (n = 39) had severe osteopenia/osteoporosis concomitant to sarcopenia. In an adjusted logistic regression model, severe osteopenia/osteoporosis (OR: 2.1; 95% CI: 0.68-6.6, p = 0.196) and sarcopenia (OR: 3.1; 95% CI: 0.88-11.1; p = 0.077) were individually associated with frailty, though not statistically significant. On the other hand, the likelihood of being frail was substantially higher in the presence of these two syndromes (OR: 6.4; 95% CI: 1.1-36.8, p=0.037). Conclusion: These findings suggest a concomitant impact of severe osteopenia/osteoporosis plus sarcopenia in regard to frailty status in a sample of oldest old women living in the community.
KW - Frailty
KW - Osteoporosis
KW - Sarcopenia
KW - Severe osteopenia
UR - http://www.scopus.com/inward/record.url?scp=79952705322&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79952705322&partnerID=8YFLogxK
U2 - 10.1016/j.bone.2010.12.025
DO - 10.1016/j.bone.2010.12.025
M3 - Article
C2 - 21195216
AN - SCOPUS:79952705322
SN - 8756-3282
VL - 48
SP - 952
EP - 957
JO - Bone
JF - Bone
IS - 4
ER -