Severe community-acquired pneumonia due to Staphylococcus aureus, 2003-04 influenza season

Jeffrey C. Hageman; Timothy M. Uyeki; John S. Francis; Daniel B. Jernigan; J. Gary Wheeler; Carolyn B. Bridges; Stephen J. Barenkamp; Dawn M. Sievert; Arjun Srinivasan; Meg C. Doherty; Linda K. McDougal; George E. Killgore; Uri A. Lopatin; Rebecca Coffman; J. Kathryn MacDonald; Sigrid K. McAllister; Gregory E. Fosheim; Jean B. Patel; L. Clifford McDonald

doi:10.3201/eid1206.051141

Severe community-acquired pneumonia due to Staphylococcus aureus, 2003-04 influenza season

Jeffrey C. Hageman, Timothy M. Uyeki, John S. Francis, Daniel B. Jernigan, J. Gary Wheeler, Carolyn B. Bridges, Stephen J. Barenkamp, Dawn M. Sievert, Arjun Srinivasan, Meg C. Doherty, Linda K. McDougal, George E. Killgore, Uri A. Lopatin, Rebecca Coffman, J. Kathryn MacDonald, Sigrid K. McAllister, Gregory E. Fosheim, Jean B. Patel, L. Clifford McDonald

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295 Scopus citations

Abstract

During the 2003-04 influenza season, 17 cases of Staphylococcus aureus community-acquired pneumonia (CAP) were reported from 9 states; 15 (88%) were associated with methicillin-resistant S. aureus (MRSA). The median age of patients was 21 years; 5 (29%) had underlying diseases, and 4 (24%) had risk factors for MRSA. Twelve (71%) had laboratory evidence of influenza virus infection. All but 1 patient, who died on arrival, were hospitalized. Death occurred in 5 (4 with MRSA). S. aureus isolates were available from 13 (76%) patients (11 MRSA). Toxin genes were detected in all isolates; 11 (85%) had only genes for Panton-Valentine leukocidin. All isolates had community-associated pulsed-field gel electrophoresis patterns; all MRSA isolates had the staphylococcal cassette chromosome mec type IVa. In communities with a high prevalence of MRSA, empiric therapy of severe CAP during periods of high influenza activity should include consideration for MRSA.

Original language	English (US)
Pages (from-to)	894-899
Number of pages	6
Journal	Emerging infectious diseases
Volume	12
Issue number	6
DOIs	https://doi.org/10.3201/eid1206.051141
State	Published - 2006
Externally published	Yes

ASJC Scopus subject areas

Epidemiology
Microbiology (medical)
Infectious Diseases

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Hageman, J. C., Uyeki, T. M., Francis, J. S., Jernigan, D. B., Wheeler, J. G., Bridges, C. B., Barenkamp, S. J., Sievert, D. M., Srinivasan, A., Doherty, M. C., McDougal, L. K., Killgore, G. E., Lopatin, U. A., Coffman, R., MacDonald, J. K., McAllister, S. K., Fosheim, G. E., Patel, J. B., & McDonald, L. C. (2006). Severe community-acquired pneumonia due to Staphylococcus aureus, 2003-04 influenza season. Emerging infectious diseases, 12(6), 894-899. https://doi.org/10.3201/eid1206.051141

Hageman, JC, Uyeki, TM, Francis, JS, Jernigan, DB, Wheeler, JG, Bridges, CB, Barenkamp, SJ, Sievert, DM, Srinivasan, A, Doherty, MC, McDougal, LK, Killgore, GE, Lopatin, UA, Coffman, R, MacDonald, JK, McAllister, SK, Fosheim, GE, Patel, JB & McDonald, LC 2006, 'Severe community-acquired pneumonia due to Staphylococcus aureus, 2003-04 influenza season', Emerging infectious diseases, vol. 12, no. 6, pp. 894-899. https://doi.org/10.3201/eid1206.051141

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title = "Severe community-acquired pneumonia due to Staphylococcus aureus, 2003-04 influenza season",

abstract = "During the 2003-04 influenza season, 17 cases of Staphylococcus aureus community-acquired pneumonia (CAP) were reported from 9 states; 15 (88%) were associated with methicillin-resistant S. aureus (MRSA). The median age of patients was 21 years; 5 (29%) had underlying diseases, and 4 (24%) had risk factors for MRSA. Twelve (71%) had laboratory evidence of influenza virus infection. All but 1 patient, who died on arrival, were hospitalized. Death occurred in 5 (4 with MRSA). S. aureus isolates were available from 13 (76%) patients (11 MRSA). Toxin genes were detected in all isolates; 11 (85%) had only genes for Panton-Valentine leukocidin. All isolates had community-associated pulsed-field gel electrophoresis patterns; all MRSA isolates had the staphylococcal cassette chromosome mec type IVa. In communities with a high prevalence of MRSA, empiric therapy of severe CAP during periods of high influenza activity should include consideration for MRSA.",

author = "Hageman, {Jeffrey C.} and Uyeki, {Timothy M.} and Francis, {John S.} and Jernigan, {Daniel B.} and Wheeler, {J. Gary} and Bridges, {Carolyn B.} and Barenkamp, {Stephen J.} and Sievert, {Dawn M.} and Arjun Srinivasan and Doherty, {Meg C.} and McDougal, {Linda K.} and Killgore, {George E.} and Lopatin, {Uri A.} and Rebecca Coffman and MacDonald, {J. Kathryn} and McAllister, {Sigrid K.} and Fosheim, {Gregory E.} and Patel, {Jean B.} and McDonald, {L. Clifford}",

year = "2006",

doi = "10.3201/eid1206.051141",

language = "English (US)",

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pages = "894--899",

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AU - Srinivasan, Arjun

AU - Doherty, Meg C.

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AU - Killgore, George E.

AU - Lopatin, Uri A.

AU - Coffman, Rebecca

AU - MacDonald, J. Kathryn

AU - McAllister, Sigrid K.

AU - Fosheim, Gregory E.

AU - Patel, Jean B.

AU - McDonald, L. Clifford

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N2 - During the 2003-04 influenza season, 17 cases of Staphylococcus aureus community-acquired pneumonia (CAP) were reported from 9 states; 15 (88%) were associated with methicillin-resistant S. aureus (MRSA). The median age of patients was 21 years; 5 (29%) had underlying diseases, and 4 (24%) had risk factors for MRSA. Twelve (71%) had laboratory evidence of influenza virus infection. All but 1 patient, who died on arrival, were hospitalized. Death occurred in 5 (4 with MRSA). S. aureus isolates were available from 13 (76%) patients (11 MRSA). Toxin genes were detected in all isolates; 11 (85%) had only genes for Panton-Valentine leukocidin. All isolates had community-associated pulsed-field gel electrophoresis patterns; all MRSA isolates had the staphylococcal cassette chromosome mec type IVa. In communities with a high prevalence of MRSA, empiric therapy of severe CAP during periods of high influenza activity should include consideration for MRSA.

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Severe community-acquired pneumonia due to Staphylococcus aureus, 2003-04 influenza season

Abstract

ASJC Scopus subject areas

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