Severe community-acquired pneumonia due to Staphylococcus aureus, 2003-04 influenza season

Jeffrey C. Hageman; Timothy M. Uyeki; John S. Francis; Daniel B. Jernigan; J. Gary Wheeler; Carolyn B. Bridges; Stephen J. Barenkamp; Dawn M. Sievert; Arjun Srinivasan; Meg C. Doherty; Linda K. McDougal; George E. Killgore; Uri A. Lopatin; Rebecca Coffman; J. Kathryn MacDonald; Sigrid K. McAllister; Gregory E. Fosheim; Jean B. Patel; L. Clifford McDonald

doi:10.3201/eid1206.051141

Severe community-acquired pneumonia due to Staphylococcus aureus, 2003-04 influenza season

Jeffrey C. Hageman, Timothy M. Uyeki, John S. Francis, Daniel B. Jernigan, J. Gary Wheeler, Carolyn B. Bridges, Stephen J. Barenkamp, Dawn M. Sievert, Arjun Srinivasan, Meg C. Doherty, Linda K. McDougal, George E. Killgore, Uri A. Lopatin, Rebecca Coffman, J. Kathryn MacDonald, Sigrid K. McAllister, Gregory E. Fosheim, Jean B. Patel, L. Clifford McDonald

Research output: Contribution to journal › Article › peer-review

295 Scopus citations

Abstract

During the 2003-04 influenza season, 17 cases of Staphylococcus aureus community-acquired pneumonia (CAP) were reported from 9 states; 15 (88%) were associated with methicillin-resistant S. aureus (MRSA). The median age of patients was 21 years; 5 (29%) had underlying diseases, and 4 (24%) had risk factors for MRSA. Twelve (71%) had laboratory evidence of influenza virus infection. All but 1 patient, who died on arrival, were hospitalized. Death occurred in 5 (4 with MRSA). S. aureus isolates were available from 13 (76%) patients (11 MRSA). Toxin genes were detected in all isolates; 11 (85%) had only genes for Panton-Valentine leukocidin. All isolates had community-associated pulsed-field gel electrophoresis patterns; all MRSA isolates had the staphylococcal cassette chromosome mec type IVa. In communities with a high prevalence of MRSA, empiric therapy of severe CAP during periods of high influenza activity should include consideration for MRSA.

Original language	English (US)
Pages (from-to)	894-899
Number of pages	6
Journal	Emerging infectious diseases
Volume	12
Issue number	6
DOIs	https://doi.org/10.3201/eid1206.051141
State	Published - 2006
Externally published	Yes

ASJC Scopus subject areas

Epidemiology
Microbiology (medical)
Infectious Diseases

Access to Document

10.3201/eid1206.051141

Cite this

Hageman, J. C., Uyeki, T. M., Francis, J. S., Jernigan, D. B., Wheeler, J. G., Bridges, C. B., Barenkamp, S. J., Sievert, D. M., Srinivasan, A., Doherty, M. C., McDougal, L. K., Killgore, G. E., Lopatin, U. A., Coffman, R., MacDonald, J. K., McAllister, S. K., Fosheim, G. E., Patel, J. B., & McDonald, L. C. (2006). Severe community-acquired pneumonia due to Staphylococcus aureus, 2003-04 influenza season. Emerging infectious diseases, 12(6), 894-899. https://doi.org/10.3201/eid1206.051141

Hageman, JC, Uyeki, TM, Francis, JS, Jernigan, DB, Wheeler, JG, Bridges, CB, Barenkamp, SJ, Sievert, DM, Srinivasan, A, Doherty, MC, McDougal, LK, Killgore, GE, Lopatin, UA, Coffman, R, MacDonald, JK, McAllister, SK, Fosheim, GE, Patel, JB & McDonald, LC 2006, 'Severe community-acquired pneumonia due to Staphylococcus aureus, 2003-04 influenza season', Emerging infectious diseases, vol. 12, no. 6, pp. 894-899. https://doi.org/10.3201/eid1206.051141

@article{5498c791247e4e86817347b8e5fcf7ef,

title = "Severe community-acquired pneumonia due to Staphylococcus aureus, 2003-04 influenza season",

abstract = "During the 2003-04 influenza season, 17 cases of Staphylococcus aureus community-acquired pneumonia (CAP) were reported from 9 states; 15 (88%) were associated with methicillin-resistant S. aureus (MRSA). The median age of patients was 21 years; 5 (29%) had underlying diseases, and 4 (24%) had risk factors for MRSA. Twelve (71%) had laboratory evidence of influenza virus infection. All but 1 patient, who died on arrival, were hospitalized. Death occurred in 5 (4 with MRSA). S. aureus isolates were available from 13 (76%) patients (11 MRSA). Toxin genes were detected in all isolates; 11 (85%) had only genes for Panton-Valentine leukocidin. All isolates had community-associated pulsed-field gel electrophoresis patterns; all MRSA isolates had the staphylococcal cassette chromosome mec type IVa. In communities with a high prevalence of MRSA, empiric therapy of severe CAP during periods of high influenza activity should include consideration for MRSA.",

author = "Hageman, {Jeffrey C.} and Uyeki, {Timothy M.} and Francis, {John S.} and Jernigan, {Daniel B.} and Wheeler, {J. Gary} and Bridges, {Carolyn B.} and Barenkamp, {Stephen J.} and Sievert, {Dawn M.} and Arjun Srinivasan and Doherty, {Meg C.} and McDougal, {Linda K.} and Killgore, {George E.} and Lopatin, {Uri A.} and Rebecca Coffman and MacDonald, {J. Kathryn} and McAllister, {Sigrid K.} and Fosheim, {Gregory E.} and Patel, {Jean B.} and McDonald, {L. Clifford}",

year = "2006",

doi = "10.3201/eid1206.051141",

language = "English (US)",

volume = "12",

pages = "894--899",

journal = "Emerging Infectious Diseases",

issn = "1080-6040",

publisher = "Centers for Disease Control and Prevention (CDC)",

number = "6",

}

TY - JOUR

T1 - Severe community-acquired pneumonia due to Staphylococcus aureus, 2003-04 influenza season

AU - Hageman, Jeffrey C.

AU - Uyeki, Timothy M.

AU - Francis, John S.

AU - Jernigan, Daniel B.

AU - Wheeler, J. Gary

AU - Bridges, Carolyn B.

AU - Barenkamp, Stephen J.

AU - Sievert, Dawn M.

AU - Srinivasan, Arjun

AU - Doherty, Meg C.

AU - McDougal, Linda K.

AU - Killgore, George E.

AU - Lopatin, Uri A.

AU - Coffman, Rebecca

AU - MacDonald, J. Kathryn

AU - McAllister, Sigrid K.

AU - Fosheim, Gregory E.

AU - Patel, Jean B.

AU - McDonald, L. Clifford

PY - 2006

Y1 - 2006

N2 - During the 2003-04 influenza season, 17 cases of Staphylococcus aureus community-acquired pneumonia (CAP) were reported from 9 states; 15 (88%) were associated with methicillin-resistant S. aureus (MRSA). The median age of patients was 21 years; 5 (29%) had underlying diseases, and 4 (24%) had risk factors for MRSA. Twelve (71%) had laboratory evidence of influenza virus infection. All but 1 patient, who died on arrival, were hospitalized. Death occurred in 5 (4 with MRSA). S. aureus isolates were available from 13 (76%) patients (11 MRSA). Toxin genes were detected in all isolates; 11 (85%) had only genes for Panton-Valentine leukocidin. All isolates had community-associated pulsed-field gel electrophoresis patterns; all MRSA isolates had the staphylococcal cassette chromosome mec type IVa. In communities with a high prevalence of MRSA, empiric therapy of severe CAP during periods of high influenza activity should include consideration for MRSA.

AB - During the 2003-04 influenza season, 17 cases of Staphylococcus aureus community-acquired pneumonia (CAP) were reported from 9 states; 15 (88%) were associated with methicillin-resistant S. aureus (MRSA). The median age of patients was 21 years; 5 (29%) had underlying diseases, and 4 (24%) had risk factors for MRSA. Twelve (71%) had laboratory evidence of influenza virus infection. All but 1 patient, who died on arrival, were hospitalized. Death occurred in 5 (4 with MRSA). S. aureus isolates were available from 13 (76%) patients (11 MRSA). Toxin genes were detected in all isolates; 11 (85%) had only genes for Panton-Valentine leukocidin. All isolates had community-associated pulsed-field gel electrophoresis patterns; all MRSA isolates had the staphylococcal cassette chromosome mec type IVa. In communities with a high prevalence of MRSA, empiric therapy of severe CAP during periods of high influenza activity should include consideration for MRSA.

UR - http://www.scopus.com/inward/record.url?scp=33744947566&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33744947566&partnerID=8YFLogxK

U2 - 10.3201/eid1206.051141

DO - 10.3201/eid1206.051141

M3 - Article

C2 - 16707043

AN - SCOPUS:33744947566

SN - 1080-6040

VL - 12

SP - 894

EP - 899

JO - Emerging Infectious Diseases

JF - Emerging Infectious Diseases

IS - 6

ER -

Severe community-acquired pneumonia due to Staphylococcus aureus, 2003-04 influenza season

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this