TY - JOUR
T1 - Severe Acute Respiratory Syndrome Coronavirus 2 Neutralizing Antibody Responses After Community Infections in Children and Adults
AU - Dawood, Fatimah S.
AU - Couture, Alexia
AU - Zhang, Xueyan
AU - Stockwell, Melissa S.
AU - Porucznik, Christina A.
AU - Stanford, Joseph B.
AU - Hetrich, Marissa
AU - Veguilla, Vic
AU - Thornburg, Natalie
AU - Heaney, Christopher D.
AU - Wang, Jing
AU - Duque, Jazmin
AU - Jeddy, Zuha
AU - Deloria Knoll, Maria
AU - Karron, Ruth
N1 - Funding Information:
Financial support. Study data were collected and managed using REDCap electronic data capture tools hosted at Vanderbilt University Medical Center with grant support UL1 TR000445 from National Center for Advancing Translational Sciences/National Institutes of Health. This study was funded by the Centers for Disease Control and Prevention via contracts 75D301-20-C-08737 with Johns Hopkins University, 75D30120C08150 with Abt Associates, and with 75D30121C10706 LabCorp .
Funding Information:
Financial support. Study data were collected and managed using REDCap electronic data capture tools hosted at Vanderbilt University Medical Center with grant support UL1 TR000445 from National Center for Advancing Translational Sciences/National Institutes of Health. This study was funded by the Centers for Disease Control and Prevention via contracts 75D301-20-C-08737 with Johns Hopkins University, 75D30120C08150 with Abt Associates, and with 75D30121C10706 LabCorp.
Funding Information:
Potential conflicts of interest. Unrelated to this work, MDK and MH received funding from Merck and Pfizer, and CAP has received personal compensation from McKesson Corporation within the past 3 years. Conflicts that the editors consider relevant to the content of the manuscript have been disclosed.
Publisher Copyright:
© 2023 Published by Oxford University Press on behalf of Infectious Diseases Society of America.
PY - 2023/5/1
Y1 - 2023/5/1
N2 - Background: We compared postinfection severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) neutralizing antibody (nAb) responses among children and adults while the D614G-like strain and Alpha, Iota, and Delta variants circulated. Methods: During August 2020-October 2021, households with adults and children were enrolled and followed in Utah, New York City, and Maryland. Participants collected weekly respiratory swabs that were tested for SARS-CoV-2 and had sera collected during enrollment and follow-up. Sera were tested for SARS-CoV-2 nAb by pseudovirus assay. Postinfection titers were characterized with biexponential decay models. Results: Eighty participants had SARS-CoV-2 infection during the study (47 with D614G-like virus, 17 with B.1.1.7, and 8 each with B.1.617.2 and B.1.526 virus). Homologous nAb geometric mean titers (GMTs) trended higher in adults (GMT = 2320) versus children 0-4 (GMT = 425, P =. 33) and 5-17 years (GMT = 396, P =. 31) at 1-5 weeks postinfection but were similar from 6 weeks. Timing of peak titers was similar by age. Results were consistent when participants with self-reported infection before enrollment were included (n = 178). Conclusions: The SARS-CoV-2 nAb titers differed in children compared to adults early after infection but were similar by 6 weeks postinfection. If postvaccination nAb kinetics have similar trends, vaccine immunobridging studies may need to compare nAb responses in adults and children 6 weeks or more after vaccination.
AB - Background: We compared postinfection severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) neutralizing antibody (nAb) responses among children and adults while the D614G-like strain and Alpha, Iota, and Delta variants circulated. Methods: During August 2020-October 2021, households with adults and children were enrolled and followed in Utah, New York City, and Maryland. Participants collected weekly respiratory swabs that were tested for SARS-CoV-2 and had sera collected during enrollment and follow-up. Sera were tested for SARS-CoV-2 nAb by pseudovirus assay. Postinfection titers were characterized with biexponential decay models. Results: Eighty participants had SARS-CoV-2 infection during the study (47 with D614G-like virus, 17 with B.1.1.7, and 8 each with B.1.617.2 and B.1.526 virus). Homologous nAb geometric mean titers (GMTs) trended higher in adults (GMT = 2320) versus children 0-4 (GMT = 425, P =. 33) and 5-17 years (GMT = 396, P =. 31) at 1-5 weeks postinfection but were similar from 6 weeks. Timing of peak titers was similar by age. Results were consistent when participants with self-reported infection before enrollment were included (n = 178). Conclusions: The SARS-CoV-2 nAb titers differed in children compared to adults early after infection but were similar by 6 weeks postinfection. If postvaccination nAb kinetics have similar trends, vaccine immunobridging studies may need to compare nAb responses in adults and children 6 weeks or more after vaccination.
KW - SARS-CoV-2
KW - adults
KW - antibodies
KW - children
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U2 - 10.1093/ofid/ofad168
DO - 10.1093/ofid/ofad168
M3 - Article
C2 - 37213425
AN - SCOPUS:85160769541
SN - 2328-8957
VL - 10
JO - Open Forum Infectious Diseases
JF - Open Forum Infectious Diseases
IS - 5
M1 - ofad168
ER -