TY - JOUR
T1 - Seventy years of tuberculosis prevention
T2 - Efficacy, effectiveness, toxicity, durability, and duration
AU - Salazar-Austin, Nicole
AU - Dowdy, David W.
AU - Chaisson, Richard E.
AU - Golub, Jonathan E.
N1 - Publisher Copyright:
© 2019 The Author(s) 2019. Published by Oxford University Press on behalf of the Johns Hopkins Bloomberg School of Public Health. All rights reserved. For permissions, please e-mail: [email protected].
PY - 2019/12/31
Y1 - 2019/12/31
N2 - Tuberculosis (TB) has been a leading infectious cause of death worldwide for much of human history, with 1.6 million deaths estimated in 2017. The Department of Epidemiology at the Johns Hopkins Bloomberg School of Public Health has played an important role in understanding and responding to TB, and it has made particularly substantial contributions to prevention of TB with chemoprophylaxis. TB preventive therapy is highly efficacious in the prevention of TB disease, yet it remains underutilized by TB programs worldwide despite strong evidence to support its use in high-risk groups, such as people living with HIV and household contacts, including those under 5 years of age. We review the evidence for TB preventive therapy and discuss the future of TB prevention.
AB - Tuberculosis (TB) has been a leading infectious cause of death worldwide for much of human history, with 1.6 million deaths estimated in 2017. The Department of Epidemiology at the Johns Hopkins Bloomberg School of Public Health has played an important role in understanding and responding to TB, and it has made particularly substantial contributions to prevention of TB with chemoprophylaxis. TB preventive therapy is highly efficacious in the prevention of TB disease, yet it remains underutilized by TB programs worldwide despite strong evidence to support its use in high-risk groups, such as people living with HIV and household contacts, including those under 5 years of age. We review the evidence for TB preventive therapy and discuss the future of TB prevention.
KW - TB preventive therapy (TPT)
KW - prevention
KW - tuberculosis
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U2 - 10.1093/aje/kwz172
DO - 10.1093/aje/kwz172
M3 - Review article
C2 - 31364692
AN - SCOPUS:85080849091
SN - 0002-9262
VL - 188
SP - 2078
EP - 2085
JO - American journal of epidemiology
JF - American journal of epidemiology
IS - 12
ER -