Serum therapy for cryptococcal meningitis

Morris A. Gordon; Arturo Casadevall

doi:10.1093/clinids/21.6.1477

Serum therapy for cryptococcal meningitis

Morris A. Gordon, Arturo Casadevall

Research output: Contribution to journal › Comment/debate › peer-review

24 Scopus citations

Abstract

Three patients were treated with combined amphotericin B and rabbit anticryptococcal antibody in the 1960s. Rabbitantibodywasadministered intravenously and waswentolerated.For each patient, administration of rabbit antibody resulted in the appearance of serum Cryptococcus neoformans agglutinins. For two patients the administration of rabbit antibody resulted in negative serum latex tests for cryptococcal antigen. This limited experience with adjunctive antibody therapy provides valuable precedents if antibody therapy is used again for treatment of human cryptococcosis.

Original language	English (US)
Pages (from-to)	1477-1479
Number of pages	3
Journal	Clinical Infectious Diseases
Volume	21
Issue number	6
DOIs	https://doi.org/10.1093/clinids/21.6.1477
State	Published - Dec 1995
Externally published	Yes

ASJC Scopus subject areas

Microbiology (medical)
Infectious Diseases

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AB - Three patients were treated with combined amphotericin B and rabbit anticryptococcal antibody in the 1960s. Rabbitantibodywasadministered intravenously and waswentolerated.For each patient, administration of rabbit antibody resulted in the appearance of serum Cryptococcus neoformans agglutinins. For two patients the administration of rabbit antibody resulted in negative serum latex tests for cryptococcal antigen. This limited experience with adjunctive antibody therapy provides valuable precedents if antibody therapy is used again for treatment of human cryptococcosis.

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Serum therapy for cryptococcal meningitis

Abstract

ASJC Scopus subject areas

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