Serum low density lipoprotein subclasses in asthma

Nicola Scichilone, Manfredi Rizzo, Alida Benfante, Roberta Catania, Rosaria Vincenza Giglio, Dragana Nikolic, Giuseppe Montalto, Vincenzo Bellia

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


Background The levels of serum low-density lipoproteins (LDL) have been implicated in the inflammatory cascade in a murine model of asthma. Recent findings suggest that LDL may modulate the inflammatory state of the asthmatic airways in humans. Objective We explored whether LDL subclasses are associated with the occurrence and severity of asthma. Methods 24 asthmatics (M/F: 11/13) and 24 healthy individuals, with normal BMI and absence of metabolic syndrome, matched for age and gender. Serum concentrations of LDL subclasses were distributed as seven bands (LDL-1 and -2 defined as large, least pro-inflammatory LDL, and LDL-3 to -7 defined as small, most pro-inflammatory LDL), using the LipoPrint© System (Quantimetrix Corporation, Redondo Beach, CA, USA). Results LDL-1 was similar in the two groups (56 ± 16% vs. 53 ± 11, p = NS), while LDL-2 was significantly lower in asthmatics as compared to controls (35 ± 8% vs. 43 ± 10%, p = 0.0074). LDL-3 levels were two-fold higher in the asthmatics, but the difference did not reach the statistical significance (8 ± 7.3% vs. 4 ± 3%, p = NS). Smaller subclasses LDL-4 to LDL-7 were undetectable in controls. In asthmatics, LDL-1 was positively associated with VC% predicted (r = +0.572, p = 0.0035) and FEV1% predicted (r = +0.492, p = 0.0146). LDL-3 was inversely correlated with both VC% predicted (r = -0.535, p = 0.0071) and FEV1% predicted (r = -0.465, p = 0.0222). Conclusions The findings of this pilot study suggest a role of LDL in asthma, and advocate for larger studies to confirm the association between asthma and dyslipidemia.

Original languageEnglish (US)
Pages (from-to)1866-1872
Number of pages7
JournalRespiratory Medicine
Issue number12
StatePublished - Dec 2013
Externally publishedYes


  • Asthma pathogenesis
  • Dyslipidemia
  • FEV
  • LDL subclasses

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine


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