Serum levels of macrophage colony stimulating factor in the patients with Alzheimer's disease

Qing li Kong, Jian min Zhang, Zhen xin Zhang, Ping jiang Ge, Ya jun Xu, Ru shun Mi, Yu hua Zhao, Yan ping Sui, Wei He

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


OBJECTIVE: To investigate the availability of serum level of macrophage clony stimulating factor (M-CSF) as a marker for early diagnosis of Alzheimer's disease (AD). METHODS: The serum levels of M-CSF in 70 patients with AD, 52 healthy controls, 22 patients with VAD (vascular dementia) were measured and the serum levels of IL-1 beta, IL-6, TNF-alpha in 32 patients with AD and 20 controls were measured as well. RESULTS: Serum levels of M-CSF were significantly elevated in patients with AD when compared with healthy controls (P <0.01) and VAD controls (P <0.05) respectively. At the early stage of mild dementia and middle dementia, serum levels of M-CSF were significantly elevated, but at the later stage of severe dementia, they returned to normal level. Serum levels of IL-1 beta were significantly elevated in AD patients compared with controls (P <0.05), and serum levels of TNF-alpha and IL-6 were within the normal range in patients with AD. CONCLUSIONS: The results suggest that serum M-CSF level may provide a convenient and sensitive means for the early diagnosis of Alzheimer's disease.

Original languageEnglish (US)
Pages (from-to)298-301
Number of pages4
JournalZhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae.
Issue number3
StatePublished - Jun 2002
Externally publishedYes

ASJC Scopus subject areas

  • General Medicine


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