Serum Adiponectin Levels, Neuroimaging, and Cognition in the Mayo Clinic Study of Aging

Alexandra M V Wennberg, Deborah Gustafson, Clinton E. Hagen, Rosebud O. Roberts, David Knopman, Clifford Jack, Ronald C. Petersen, Michelle M. Mielke, Gene Bowman

Research output: Contribution to journalArticlepeer-review

40 Scopus citations


Background: Adiponectin, a protein involved in inflammatory pathways, may impact the development and progression of Alzheimer's disease (AD). Adiponectin levels have been associated with mild cognitive impairment (MCI) and AD; however, its association with Alzheimer-associated neuroimaging and cognitive outcomes is unknown. Objective: Determine the cross-sectional association between plasma adiponectin and neuroimaging and cognitive outcomes in an older population-based sample. Methods: Multivariable adjusted regression models were used to investigate the association between plasma adiponectin and hippocampal volume (HVa), PiB-PET, FDG PET, cortical thickness, MCI diagnosis, and neuropsychological test performance. Analyses included 535 non-demented participants aged 70 and older enrolled in the Mayo Clinic Study of Aging. Results: Women had higher adiponectin than men (12,631ng/mL versus 8,908ng/mL, p1.4), among women with elevated amyloid, higher adiponectin was associated with smaller HVa (B=-0.723; 95 CI -1.43, -0.014), poorer performance in memory (B=-1.02; 95 CI -1.73, -0.312), language (B=-0.896; 95 CI -1.58, -0.212), global cognition (B=-0.650; 95 CI -1.18, -0.116), and greater odds of MCI (OR=19.34; 95 CI 2.72, 137.34). Conclusion: Higher plasma adiponectin was associated with neuroimaging and cognitive outcomes among women. Longitudinal analyses are necessary to determine whether higher adiponectin predicts neurodegeneration and cognitive decline.

Original languageEnglish (US)
Pages (from-to)573-581
Number of pages9
JournalJournal of Alzheimer's Disease
Issue number2
StatePublished - 2016
Externally publishedYes


  • Adiponectin
  • Amyloid-PET
  • Cognition
  • Hippocampal volume
  • Mild cognitive impairment

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Geriatrics and Gerontology
  • Clinical Psychology


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