Serous borderline (low malignant potential, atypical proliferative) ovarian tumors: Workshop perspectives

Debra A. Bell, Teri A. Longacre, Jaime Prat, Elise C. Kohn, Robert A. Soslow, Lora H. Ellenson, Anais Malpica, Mark H. Stoler, Robert J. Kurman

Research output: Contribution to journalArticlepeer-review

117 Scopus citations


Although the category of serous borderline ovarian tumor (S-BOT) was established more than 30 years ago, the nomenclature and prognostic significance of various histological features of these neoplasms continues to engender controversy. The Borderline Ovarian Tumor Workshop was held in Bethesda, MD, in August 2003 in an attempt to examine the existing data, establish areas of agreement, and identify areas needing further investigation. This report addresses 6 areas of controversy regarding S-BOT: (1) tumors with and without a micropapillary architecture (typical vs micropapillary type), (2) peritoneal implants, (3) stromal microinvasion, (4) ovarian surface involvement, (5) lymph node involvement, and (6) recurrent tumors. Each of these issues is addressed by summarizing the data in the literature on which the discussions were based, areas of agreement that emerged, divergent opinions and the reasoning behind them, and the conclusions of the participants with recommended nomenclature.

Original languageEnglish (US)
Pages (from-to)934-948
Number of pages15
JournalHuman pathology
Issue number8
StatePublished - Aug 2004


  • S-BOT
  • atypical proliferative
  • borderline
  • low malignant potential
  • ovary
  • serous
  • serous borderline ovarian tumor

ASJC Scopus subject areas

  • Pathology and Forensic Medicine


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