TY - JOUR
T1 - Serotonin 2A Receptor Signaling Underlies LSD-induced Alteration of the Neural Response to Dynamic Changes in Music
AU - Barrett, Frederick S.
AU - Preller, Katrin H.
AU - Herdener, Marcus
AU - Janata, Petr
AU - Vollenweider, Franz X.
N1 - Funding Information:
The Heffter Research Institute (1-190 413), the Swiss Neuromatrix Foundation (2015-0103), the Usona Institute (2015-2056) to F.X.V., and the Swiss National Science Foundation (SNSF, P2ZHP1_161626) to K.H.P. F.S.B. was partially supported by NIH grant R03DA042336.
Publisher Copyright:
© The Author 2017. Published by Oxford University Press. All rights reserved.
PY - 2018/11/1
Y1 - 2018/11/1
N2 - Classic psychedelic drugs (serotonin 2A, or 5HT 2A, receptor agonists) have notable effects on music listening. In the current report, blood oxygen level-dependent (BOLD) signal was collected during music listening in 25 healthy adults after administration of placebo, lysergic acid diethylamide (LSD), and LSD pretreated with the 5HT 2A antagonist ketanserin, to investigate the role of 5HT 2A receptor signaling in the neural response to the time-varying tonal structure of music. Tonality-tracking analysis of BOLD data revealed that 5HT 2A receptor signaling alters the neural response to music in brain regions supporting basic and higher-level musical and auditory processing, and areas involved in memory, emotion, and self-referential processing. This suggests a critical role of 5HT 2A receptor signaling in supporting the neural tracking of dynamic tonal structure in music, as well as in supporting the associated increases in emotionality, connectedness, and meaningfulness in response to music that are commonly observed after the administration of LSD and other psychedelics. Together, these findings inform the neuropsychopharmacology of music perception and cognition, meaningful music listening experiences, and altered perception of music during psychedelic experiences.
AB - Classic psychedelic drugs (serotonin 2A, or 5HT 2A, receptor agonists) have notable effects on music listening. In the current report, blood oxygen level-dependent (BOLD) signal was collected during music listening in 25 healthy adults after administration of placebo, lysergic acid diethylamide (LSD), and LSD pretreated with the 5HT 2A antagonist ketanserin, to investigate the role of 5HT 2A receptor signaling in the neural response to the time-varying tonal structure of music. Tonality-tracking analysis of BOLD data revealed that 5HT 2A receptor signaling alters the neural response to music in brain regions supporting basic and higher-level musical and auditory processing, and areas involved in memory, emotion, and self-referential processing. This suggests a critical role of 5HT 2A receptor signaling in supporting the neural tracking of dynamic tonal structure in music, as well as in supporting the associated increases in emotionality, connectedness, and meaningfulness in response to music that are commonly observed after the administration of LSD and other psychedelics. Together, these findings inform the neuropsychopharmacology of music perception and cognition, meaningful music listening experiences, and altered perception of music during psychedelic experiences.
KW - functional magnetic resonance imaging (fMRI)
KW - music information retrieval
KW - psychedelics
KW - tonality
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U2 - 10.1093/cercor/bhx257
DO - 10.1093/cercor/bhx257
M3 - Article
C2 - 29028939
AN - SCOPUS:85042779376
SN - 1047-3211
VL - 28
SP - 3939
EP - 3950
JO - Cerebral Cortex
JF - Cerebral Cortex
IS - 11
ER -