Seronegative HIV-1 infection: A review of the literature

Adam M. Spivak, Emily R.M. Sydnor, Joel N. Blankson, Joel E. Gallant

Research output: Contribution to journalReview articlepeer-review

17 Scopus citations


HIV-1-specific antibodies can be detected in HIV-1-positive patients within weeks of primary infection. Rare cases have been reported of patients who are persistently seronegative despite evidence of HIV-1 infection. We present a retrospective review of the clinical, virologic and immunologic characteristics of 25 persistently seronegative patients whose cases have been published to date and postulate a biologic mechanism for this phenomenon.

Original languageEnglish (US)
Pages (from-to)1407-1414
Number of pages8
Issue number10
StatePublished - Jun 19 2010


  • HIV diagnosis
  • HIV seronegativity
  • acute seroconversion
  • rapid HIV progression

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases


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