Seronegative HIV-1 infection: A review of the literature

Adam M. Spivak; Emily R.M. Sydnor; Joel N. Blankson; Joel E. Gallant

doi:10.1097/QAD.0b013e32833ac65c

Seronegative HIV-1 infection: A review of the literature

Adam M. Spivak, Emily R.M. Sydnor, Joel N. Blankson, Joel E. Gallant

School of Medicine

Research output: Contribution to journal › Review article › peer-review

17 Scopus citations

Abstract

HIV-1-specific antibodies can be detected in HIV-1-positive patients within weeks of primary infection. Rare cases have been reported of patients who are persistently seronegative despite evidence of HIV-1 infection. We present a retrospective review of the clinical, virologic and immunologic characteristics of 25 persistently seronegative patients whose cases have been published to date and postulate a biologic mechanism for this phenomenon.

Original language	English (US)
Pages (from-to)	1407-1414
Number of pages	8
Journal	AIDS
Volume	24
Issue number	10
DOIs	https://doi.org/10.1097/QAD.0b013e32833ac65c
State	Published - Jun 19 2010

Keywords

HIV diagnosis
HIV seronegativity
acute seroconversion
rapid HIV progression

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Infectious Diseases

Access to Document

10.1097/QAD.0b013e32833ac65c

Cite this

@article{1be22e21b34c491fb6b671ee70e9f925,

title = "Seronegative HIV-1 infection: A review of the literature",

abstract = "HIV-1-specific antibodies can be detected in HIV-1-positive patients within weeks of primary infection. Rare cases have been reported of patients who are persistently seronegative despite evidence of HIV-1 infection. We present a retrospective review of the clinical, virologic and immunologic characteristics of 25 persistently seronegative patients whose cases have been published to date and postulate a biologic mechanism for this phenomenon.",

keywords = "HIV diagnosis, HIV seronegativity, acute seroconversion, rapid HIV progression",

author = "Spivak, {Adam M.} and Sydnor, {Emily R.M.} and Blankson, {Joel N.} and Gallant, {Joel E.}",

year = "2010",

month = jun,

day = "19",

doi = "10.1097/QAD.0b013e32833ac65c",

language = "English (US)",

volume = "24",

pages = "1407--1414",

journal = "AIDS",

issn = "0269-9370",

publisher = "Lippincott Williams and Wilkins",

number = "10",

}

TY - JOUR

T1 - Seronegative HIV-1 infection

T2 - A review of the literature

AU - Spivak, Adam M.

AU - Sydnor, Emily R.M.

AU - Blankson, Joel N.

AU - Gallant, Joel E.

PY - 2010/6/19

Y1 - 2010/6/19

N2 - HIV-1-specific antibodies can be detected in HIV-1-positive patients within weeks of primary infection. Rare cases have been reported of patients who are persistently seronegative despite evidence of HIV-1 infection. We present a retrospective review of the clinical, virologic and immunologic characteristics of 25 persistently seronegative patients whose cases have been published to date and postulate a biologic mechanism for this phenomenon.

AB - HIV-1-specific antibodies can be detected in HIV-1-positive patients within weeks of primary infection. Rare cases have been reported of patients who are persistently seronegative despite evidence of HIV-1 infection. We present a retrospective review of the clinical, virologic and immunologic characteristics of 25 persistently seronegative patients whose cases have been published to date and postulate a biologic mechanism for this phenomenon.

KW - HIV diagnosis

KW - HIV seronegativity

KW - acute seroconversion

KW - rapid HIV progression

UR - http://www.scopus.com/inward/record.url?scp=77953914239&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77953914239&partnerID=8YFLogxK

U2 - 10.1097/QAD.0b013e32833ac65c

DO - 10.1097/QAD.0b013e32833ac65c

M3 - Review article

C2 - 20467287

AN - SCOPUS:77953914239

SN - 0269-9370

VL - 24

SP - 1407

EP - 1414

JO - AIDS

JF - AIDS

IS - 10

ER -

Seronegative HIV-1 infection: A review of the literature

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this