Seroconversion following anal and genital HPV infection in men: The HIM study

Anna R. Giuliano, Raphael Viscidi, B. Nelson Torres, Donna J. Ingles, Staci L. Sudenga, Luisa L. Villa, Maria Luiza Baggio, Martha Abrahamsen, Manuel Quiterio, Jorge Salmeron, Eduardo Lazcano-Ponce

Research output: Contribution to journalArticlepeer-review

31 Scopus citations


Background: Protection from naturally acquired human papillomavirus (HPV) antibodies may influence HPV infection across the lifespan. This study describes seroconversion rates following genital, anal, and oral HPV 6/11/16/18 infections in men and examines differences by HPV type and anatomic site. Methods: Men with HPV 6/11/16/18 infections who were seronegative for those genotypes at the time of DNA detection were selected from the HPV Infection in Men (HIM) Study. Sera specimens collected ≤36 months after detection were analyzed for HPV 6/11/16/18 antibodies using a virus-like particle-based ELISA. Time to seroconversion was separately assessed for each anatomic site, stratified by HPV type. Results: Seroconversion to ≥1 HPV type (6/11/16/18) in this sub-cohort (N=384) varied by anatomic site, with 6.3%, 18.9%, and 0.0% seroconverting following anal, genital, and oral HPV infection, respectively. Regardless of anatomic site, seroconversion was highest for HPV 6 (19.3%). Overall, seroconversion was highest following anal HPV 6 infection (69.2%). HPV persistence was the only factor found to influence seroconversion. Conclusions: Low seroconversion rates following HPV infection leave men susceptible to recurrent infections that can progress to HPV-related cancers. This emphasizes the need for HPV vaccination in men to ensure immune protection against new HPV infections and subsequent disease.

Original languageEnglish (US)
Pages (from-to)109-115
Number of pages7
JournalPapillomavirus Research
StatePublished - Dec 1 2015


  • HPV
  • HPV antibodies
  • Human papillomavirus
  • Men
  • Seroconversion

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases


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