TY - JOUR
T1 - Serial assessment of MIBG scintigraphy in a case of DCM with heart failure improved by β-blocker therapy
AU - Yamamoto, K.
AU - Asada, S.
AU - Yabunouchi, T.
AU - Morozumi, R.
AU - Kusuoka, H.
AU - Nishimura, T.
PY - 1995
Y1 - 1995
N2 - We experienced a case of DCM (62-year-old man) improved by β-blocker (Metoprolol) therapy and studied time course of MIBG scintigraphy. We measured cardiac functions by UCG and 99mTc cardiac pool imaging, and MIBG scintigraphy during 12 months of β-blocker therapy. In planar images we measured washout rate (WR) in total myocardium and regional washout rate (rWR) in 6 segments of myocardium. Cardiac function improved after 3 months of therapy. The WR did not improve until 6 months, but improved after 9 months (Before: 35.1%, 3 months after: 34.6%, 6 months after: 33.6%, 9 months after: 27.6%, 12 months after: 25.4%). rWR in inferoapical segment first improved at 3 months (Before: 40.1%, 3 months after: 35.1%), whereas rWR in antero-apical segment improved after 6 months and that in anterior segment improved after 9 months. These results suggest that the improvement of cardiac sympathetic nerve function in DCM treated with β-blocker was not identical in each myocardium region.
AB - We experienced a case of DCM (62-year-old man) improved by β-blocker (Metoprolol) therapy and studied time course of MIBG scintigraphy. We measured cardiac functions by UCG and 99mTc cardiac pool imaging, and MIBG scintigraphy during 12 months of β-blocker therapy. In planar images we measured washout rate (WR) in total myocardium and regional washout rate (rWR) in 6 segments of myocardium. Cardiac function improved after 3 months of therapy. The WR did not improve until 6 months, but improved after 9 months (Before: 35.1%, 3 months after: 34.6%, 6 months after: 33.6%, 9 months after: 27.6%, 12 months after: 25.4%). rWR in inferoapical segment first improved at 3 months (Before: 40.1%, 3 months after: 35.1%), whereas rWR in antero-apical segment improved after 6 months and that in anterior segment improved after 9 months. These results suggest that the improvement of cardiac sympathetic nerve function in DCM treated with β-blocker was not identical in each myocardium region.
KW - I-metaiodobenzylguanidine
KW - beta-blocker therapy
KW - dilated cardiomyopathy
KW - regional washout rate
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M3 - Article
C2 - 7776548
AN - SCOPUS:0029038267
SN - 0022-7854
VL - 32
SP - 413
EP - 418
JO - Kaku igaku. The Japanese journal of nuclear medicine
JF - Kaku igaku. The Japanese journal of nuclear medicine
IS - 4
ER -