Sequence variations in CREB1 cosegregate with depressive disorders in women

G. S. Zubenko; H. B. Hughes; J. S. Stiffler; A. Brechbiel; W. N. Zubenko; B. S. Maher; M. L. Marazita

doi:10.1038/sj.mp.4001354

Sequence variations in CREB1 cosegregate with depressive disorders in women

G. S. Zubenko, H. B. Hughes, J. S. Stiffler, A. Brechbiel, W. N. Zubenko, B. S. Maher, M. L. Marazita

Research output: Contribution to journal › Article › peer-review

78 Scopus citations

Abstract

Major depressive disorder (MDD) constitutes a major public health problem worldwide and affects women twice as frequently as men. Previous linkage studies have identified a 451 kb region of 2q33-35 that exhibited significant evidence of linkage to Mood Disorders among women (but not men) from families with recurrent, early-onset MDD (RE-MDD), a severe and strongly familial subtype of MDD. This 451kb region includes CREB1, an attractive susceptibility gene for MDD and related disorders. Sequence variations in the CREB1 promoter and intron 8 have been detected that cosegregate with Mood Disorders, or their absence, in women from these families, identifying CREB1 as a sex-limited susceptibility gene for unipolar Mood Disorders. These findings implicate the cAMP signaling pathway in the pathophysiology of Mood Disorders and related conditions.

Original language	English (US)
Pages (from-to)	611-618
Number of pages	8
Journal	Molecular psychiatry
Volume	8
Issue number	6
DOIs	https://doi.org/10.1038/sj.mp.4001354
State	Published - 2003
Externally published	Yes

Keywords

CREB1
Depression
Genetics
Sex-specific
Women

ASJC Scopus subject areas

Molecular Biology
Psychiatry and Mental health
Cellular and Molecular Neuroscience

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10.1038/sj.mp.4001354

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title = "Sequence variations in CREB1 cosegregate with depressive disorders in women",

abstract = "Major depressive disorder (MDD) constitutes a major public health problem worldwide and affects women twice as frequently as men. Previous linkage studies have identified a 451 kb region of 2q33-35 that exhibited significant evidence of linkage to Mood Disorders among women (but not men) from families with recurrent, early-onset MDD (RE-MDD), a severe and strongly familial subtype of MDD. This 451kb region includes CREB1, an attractive susceptibility gene for MDD and related disorders. Sequence variations in the CREB1 promoter and intron 8 have been detected that cosegregate with Mood Disorders, or their absence, in women from these families, identifying CREB1 as a sex-limited susceptibility gene for unipolar Mood Disorders. These findings implicate the cAMP signaling pathway in the pathophysiology of Mood Disorders and related conditions.",

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author = "Zubenko, {G. S.} and Hughes, {H. B.} and Stiffler, {J. S.} and A. Brechbiel and Zubenko, {W. N.} and Maher, {B. S.} and Marazita, {M. L.}",

note = "Funding Information: The previous contributions of the research staff of this project, and the families who participated, are gratefully acknowledged. This work was supported by research project Grants MH48969 and MH60866 (GSZ). Automated DNA sequencing was performed by the Genomics and Proteomics Core Laboratories of the University of Pittsburgh. Some of the results of this study were obtained using S.A.G.E., supported by US Public Health Service Resource Grant 1-P41-RR03655. GSZ was the recipient of Independent Scientist Award MH00540 from the National Institute of Mental Health.",

year = "2003",

doi = "10.1038/sj.mp.4001354",

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AU - Hughes, H. B.

AU - Stiffler, J. S.

AU - Brechbiel, A.

AU - Zubenko, W. N.

AU - Maher, B. S.

AU - Marazita, M. L.

N1 - Funding Information: The previous contributions of the research staff of this project, and the families who participated, are gratefully acknowledged. This work was supported by research project Grants MH48969 and MH60866 (GSZ). Automated DNA sequencing was performed by the Genomics and Proteomics Core Laboratories of the University of Pittsburgh. Some of the results of this study were obtained using S.A.G.E., supported by US Public Health Service Resource Grant 1-P41-RR03655. GSZ was the recipient of Independent Scientist Award MH00540 from the National Institute of Mental Health.

PY - 2003

Y1 - 2003

N2 - Major depressive disorder (MDD) constitutes a major public health problem worldwide and affects women twice as frequently as men. Previous linkage studies have identified a 451 kb region of 2q33-35 that exhibited significant evidence of linkage to Mood Disorders among women (but not men) from families with recurrent, early-onset MDD (RE-MDD), a severe and strongly familial subtype of MDD. This 451kb region includes CREB1, an attractive susceptibility gene for MDD and related disorders. Sequence variations in the CREB1 promoter and intron 8 have been detected that cosegregate with Mood Disorders, or their absence, in women from these families, identifying CREB1 as a sex-limited susceptibility gene for unipolar Mood Disorders. These findings implicate the cAMP signaling pathway in the pathophysiology of Mood Disorders and related conditions.

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Sequence variations in CREB1 cosegregate with depressive disorders in women

Abstract

Keywords

ASJC Scopus subject areas

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