@article{4bb34cebfe7c42e2841cdbb3201c0656,
title = "Septo-optic dysplasia",
abstract = "Septo-optic dysplasia is a rare disorder characterized by optic nerve hypoplasia; midline developmental defects including agenesis of the septum pellucidum, thinning or absence of the corpus callosum, or both; and deficiencies of pituitary hormones. The majority of cases are sporadic but rare familial cases occur. The clinical manifestations include poor visual function in one or both eyes, developmental delay, seizures, sleep disturbances, and precocious puberty. A life-long multidisciplinary approach is crucial in the management of these patients to optimize their growth and development and to help them lead as normal lives as possible.",
keywords = "Agenesis of the corpus callosum, Hypopituitarism, Optic nerve hypoplasia, Septo-optic dysplasia, Septum pellucidum",
author = "Fard, {M. A.} and Wu-Chen, {W. Y.} and Man, {B. L.} and Miller, {Niel R.}",
note = "Funding Information: as in the previous one, a highly significant difference (P< 0-001) exists between the congenital-heart-disease and the control groups with respect to a positive family history of C.H.D. In contrast to the previous series, a significant difference also exists for maternal exposure to dexamphe- tamine at the vulnerable period (P=0-025) and at any time during pregnancy (p < 0-05). Although we recognise the serious deficiencies in retro- spective studies in general, and in ours in particular, the present study has created enough doubt in our minds to prompt us to withdraw our previous statement of {"} no causal association between maternal dexamphetamine exposure and C.H.D.{"} This is our first purpose in writing. Our second purpose is to encourage investigators with large prospective series to look specifically at dexampheta- mine, since our prospective study is too small to yield meaningful information. This work was supported by grants Foundation-March of Dimes and National Institutes of Health HE 5756 and HE 5752. Copyright: Copyright 2011 Elsevier B.V., All rights reserved.",
year = "2010",
month = sep,
language = "English (US)",
volume = "8",
pages = "18--24",
journal = "Pediatric Endocrinology Reviews",
issn = "1565-4753",
publisher = "YS Medical Media Ltd.",
number = "1",
}