Septic-associated encephalopathy - everything starts at a microlevel

Tarek Sharshar, Andrea Polito, Anthony Checinski, Robert D. Stevens

Research output: Contribution to journalComment/debatepeer-review

31 Scopus citations


Sepsis-associated encephalopathy is associated with increased mortality and morbidity. Its pathophysiology remains insufficiently elucidated, although there is evidence for a neuroinflammatory process sequentially involving endothelial activation, blood-brain barrier alteration and cellular dysfunction and alteration in neurotransmission. Experimental studies have shown that microcirculatory dysfunction, a consequence of endothelial activation, is an early pathogenic step. To date, we do not know whether it is present in septic patients, whether it accounts for clinical features and whether it is treatable.

Original languageEnglish (US)
Article number199
JournalCritical Care
Issue number5
StatePublished - Sep 29 2010

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine


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