TY - JOUR
T1 - Sensorimotor Plasticity after Music-Supported Therapy in Chronic Stroke Patients Revealed by Transcranial Magnetic Stimulation
AU - Amengual, Julià L.
AU - Rojo, Nuria
AU - Veciana de las Heras, Misericordia
AU - Marco-Pallarés, Josep
AU - Grau-Sánchez, Jennifer
AU - Schneider, Sabine
AU - Vaquero, Lucía
AU - Juncadella, Montserrat
AU - Montero, Jordi
AU - Mohammadi, Bahram
AU - Rubio, Francisco
AU - Rueda, Nohora
AU - Duarte, Esther
AU - Grau, Carles
AU - Altenmüller, Eckart
AU - Münte, Thomas F.
AU - Rodríguez-Fornells, Antoni
PY - 2013/4/17
Y1 - 2013/4/17
N2 - Background:Several recently developed therapies targeting motor disabilities in stroke sufferers have shown to be more effective than standard neurorehabilitation approaches. In this context, several basic studies demonstrated that music training produces rapid neuroplastic changes in motor-related brain areas. Music-supported therapy has been recently developed as a new motor rehabilitation intervention.Methods and Results:In order to explore the plasticity effects of music-supported therapy, this therapeutic intervention was applied to twenty chronic stroke patients. Before and after the music-supported therapy, transcranial magnetic stimulation was applied for the assessment of excitability changes in the motor cortex and a 3D movement analyzer was used for the assessment of motor performance parameters such as velocity, acceleration and smoothness in a set of diadochokinetic movement tasks. Our results suggest that the music-supported therapy produces changes in cortical plasticity leading the improvement of the subjects' motor performance.Conclusion:Our findings represent the first evidence of the neurophysiological changes induced by this therapy in chronic stroke patients, and their link with the amelioration of motor performance. Further studies are needed to confirm our observations.
AB - Background:Several recently developed therapies targeting motor disabilities in stroke sufferers have shown to be more effective than standard neurorehabilitation approaches. In this context, several basic studies demonstrated that music training produces rapid neuroplastic changes in motor-related brain areas. Music-supported therapy has been recently developed as a new motor rehabilitation intervention.Methods and Results:In order to explore the plasticity effects of music-supported therapy, this therapeutic intervention was applied to twenty chronic stroke patients. Before and after the music-supported therapy, transcranial magnetic stimulation was applied for the assessment of excitability changes in the motor cortex and a 3D movement analyzer was used for the assessment of motor performance parameters such as velocity, acceleration and smoothness in a set of diadochokinetic movement tasks. Our results suggest that the music-supported therapy produces changes in cortical plasticity leading the improvement of the subjects' motor performance.Conclusion:Our findings represent the first evidence of the neurophysiological changes induced by this therapy in chronic stroke patients, and their link with the amelioration of motor performance. Further studies are needed to confirm our observations.
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U2 - 10.1371/journal.pone.0061883
DO - 10.1371/journal.pone.0061883
M3 - Article
C2 - 23613966
AN - SCOPUS:84876240126
SN - 1932-6203
VL - 8
JO - PloS one
JF - PloS one
IS - 4
M1 - e61883
ER -