Sensitivity enhancement of phase-sensitive surface plasmon resonance biosensor using multi-pass interferometry

W. Yuan, H. P. Ho, C. L. Wong, S. Y. Wu, Y. K. Suen, S. K. Kong, Chinlon Lin

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Scopus citations

Abstract

A novel design of multi-pass phase-sensitive surface plasmon resonance (SPR) biosensor is presented. The system is based on differential phase interrogation scheme incorporated to the Michelson or Fabry-Perot interferometer configuration. An intrinsic phase amplification effect is achieved by placing the SPR sensor head in the signal arm of the interferometer so that the interrogating optical beam traverses the sensor surface multiple times. Experimental results obtained from antibody-antigen and protein-DNA binding reaction using both the Michelson and Fabry-Perot interferometer configurations indeed demonstrate the expected phase amplifications factors of 2 and 2.26 respectively in comparison to that obtained by the conventional Mach-Zehnder interferometer configuration. This phase amplification effect leads to the sensitivity enhancement and corresponding resolution improvement by at least 2 times.

Original languageEnglish (US)
Title of host publicationProceedings of International Symposium on Biophotonics, Nanophotonics and Metamaterials, Metamaterials 2006
Pages202-205
Number of pages4
DOIs
StatePublished - 2006
Externally publishedYes
EventInternational Symposium on Biophotonics, Nanophotonics and Metamaterials, Metamaterials 2006 - Hangzhou, China
Duration: Oct 16 2006Oct 18 2006

Publication series

NameProceedings of International Symposium on Biophotonics, Nanophotonics and Metamaterials, Metamaterials 2006

Other

OtherInternational Symposium on Biophotonics, Nanophotonics and Metamaterials, Metamaterials 2006
Country/TerritoryChina
CityHangzhou
Period10/16/0610/18/06

ASJC Scopus subject areas

  • Biotechnology
  • Biomaterials
  • Electronic, Optical and Magnetic Materials

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