TY - JOUR
T1 - Semaphorins and the dynamic regulation of synapse assembly, refinement, and function
AU - Koropouli, Eleftheria
AU - Kolodkin, Alex L.
N1 - Funding Information:
We thank Suzanne Paradis, Jeroen Pasterkamp and Martín Riccomagno for critical reading of this manuscript. Work cited here from the authors’ laboratory was supported by the NIH and the Howard Hughes Medical Institute. ALK is an investigator of the Howard Hughes Medical Institute.
PY - 2014/8
Y1 - 2014/8
N2 - Semaphorins are phylogenetically conserved proteins expressed in most organ systems, including the nervous system. Following their description as axon guidance cues, semaphorins have been implicated in multiple aspects of nervous system development. Semaphorins are key regulators of neural circuit assembly, neuronal morphogenesis, assembly of excitatory and inhibitory synapses, and synaptic refinement. Semaphorins contribute to the balance between excitatory and inhibitory synaptic transmission, and electrical activity can modulate semaphorin signaling in neurons. This interplay between guidance cue signaling and electrical activity has the potential to sculpt the wiring of neural circuits and to modulate their function.
AB - Semaphorins are phylogenetically conserved proteins expressed in most organ systems, including the nervous system. Following their description as axon guidance cues, semaphorins have been implicated in multiple aspects of nervous system development. Semaphorins are key regulators of neural circuit assembly, neuronal morphogenesis, assembly of excitatory and inhibitory synapses, and synaptic refinement. Semaphorins contribute to the balance between excitatory and inhibitory synaptic transmission, and electrical activity can modulate semaphorin signaling in neurons. This interplay between guidance cue signaling and electrical activity has the potential to sculpt the wiring of neural circuits and to modulate their function.
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U2 - 10.1016/j.conb.2014.02.005
DO - 10.1016/j.conb.2014.02.005
M3 - Review article
C2 - 24598309
AN - SCOPUS:84896900352
SN - 0959-4388
VL - 27
SP - 1
EP - 7
JO - Current Opinion in Neurobiology
JF - Current Opinion in Neurobiology
ER -