TY - JOUR
T1 - Self-reported metabolic risk factor associations with adenomatous, sessile serrated, and synchronous adenomatous and sessile serrated polyps
AU - Biofilm Study Consortium
AU - Santiago, Celina N.
AU - Rifkin, Samara
AU - Drewes, Julia
AU - Mullin, Gerard
AU - Spence, Emma
AU - Hylind, Linda M.
AU - Gills, Joell J.
AU - Kafonek, David
AU - Cromwell, David M.
AU - Luna, Louis La
AU - Giardello, Francis
AU - Sears, Cynthia L.
AU - Stevens, Courtney
AU - Tabisz, Brent
AU - Bedine, Marshall
AU - Gonzalez-Velez, Eduardo
AU - Galon Veloso, Hazel Marie
AU - Schearer, Pamela
AU - Gerhart, Stacy
AU - Schiller, Amy
AU - Donato, Karin
AU - Sweigart, Randi
AU - Altomare, John
AU - Shah, Nirav
AU - Ibrahim, Christopher
AU - Ghanta, Ravi
N1 - Publisher Copyright:
© 2021 American Association for Cancer Research.
PY - 2021/7
Y1 - 2021/7
N2 - Studies have found a positive association between metabolic risk factors, such as obesity and diabetes, and adenomatous polyps (AP). However, fewer studies have assessed the association between sessile serrated polyps (SSP) or synchronous diagnosis of APs and SSPs (synch polyps). Study participants (N ¼ 1,370; ages 40–85) undergoing screening colonoscopy were enrolled between August 2016 and February 2020. Self-reported metabolic risk factors, including diabetes, hypertension, hyperlipidemia, and overweight/obesity, were evaluated for associations with new diagnoses of APs, SSPs, and synch polyps at the present colonoscopy. Average participant age was 60.73 ± 8.63 (SD) years; 56.7% were female and 90.9% white. In an assessment of individual metabolic risk factors, adjusted for age, sex, race, and smoking status, increased body mass index (BMI; overweight or obese vs. normal BMI of <25 kg/m2) was associated with an increased odds for new onset of colon APs (Ptrend < 0.001) as was a diagnosis of diabetes [adjusted conditional OR (aCOR) ¼ 1.59 (1.10–2.29)]. No associations were seen between the metabolic risk factors and onset of SSPs. Being obese or hypertensive each increased the odds of new onset of synch polyps with aCOR values of 2.09 (1.01–4.32) and 1.79 (1.06–3.02), respectively. Self-reported risk factors may help assess polyp type risk. Because SSPs and synch polyps are rare, larger studies are needed to improve our understanding of the contribution of these factors to polyp risk. These data lead us to hypothesize that differences in observed metabolic risk factors between polyp types reflect select metabolic impact on pathways to colorectal cancer. Prevention Relevance: Self-reported medical history provides valuable insight into polyp risk, potentially enabling the use of larger retrospective studies of colonoscopy populations to assess knowledge gaps. More aggressive colonoscopy screening, critical to colorectal cancer prevention, may be considered in populations of individuals with metabolic risk factors and modifiable lifestyle risk factors.
AB - Studies have found a positive association between metabolic risk factors, such as obesity and diabetes, and adenomatous polyps (AP). However, fewer studies have assessed the association between sessile serrated polyps (SSP) or synchronous diagnosis of APs and SSPs (synch polyps). Study participants (N ¼ 1,370; ages 40–85) undergoing screening colonoscopy were enrolled between August 2016 and February 2020. Self-reported metabolic risk factors, including diabetes, hypertension, hyperlipidemia, and overweight/obesity, were evaluated for associations with new diagnoses of APs, SSPs, and synch polyps at the present colonoscopy. Average participant age was 60.73 ± 8.63 (SD) years; 56.7% were female and 90.9% white. In an assessment of individual metabolic risk factors, adjusted for age, sex, race, and smoking status, increased body mass index (BMI; overweight or obese vs. normal BMI of <25 kg/m2) was associated with an increased odds for new onset of colon APs (Ptrend < 0.001) as was a diagnosis of diabetes [adjusted conditional OR (aCOR) ¼ 1.59 (1.10–2.29)]. No associations were seen between the metabolic risk factors and onset of SSPs. Being obese or hypertensive each increased the odds of new onset of synch polyps with aCOR values of 2.09 (1.01–4.32) and 1.79 (1.06–3.02), respectively. Self-reported risk factors may help assess polyp type risk. Because SSPs and synch polyps are rare, larger studies are needed to improve our understanding of the contribution of these factors to polyp risk. These data lead us to hypothesize that differences in observed metabolic risk factors between polyp types reflect select metabolic impact on pathways to colorectal cancer. Prevention Relevance: Self-reported medical history provides valuable insight into polyp risk, potentially enabling the use of larger retrospective studies of colonoscopy populations to assess knowledge gaps. More aggressive colonoscopy screening, critical to colorectal cancer prevention, may be considered in populations of individuals with metabolic risk factors and modifiable lifestyle risk factors.
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U2 - 10.1158/1940-6207.CAPR-20-0664
DO - 10.1158/1940-6207.CAPR-20-0664
M3 - Article
C2 - 33947705
AN - SCOPUS:85109169284
SN - 1940-6207
VL - 14
SP - 697
EP - 708
JO - Cancer Prevention Research
JF - Cancer Prevention Research
IS - 7 July
ER -