Self-reported gastrointestinal symptoms in type 2 diabetes improve with an intensive lifestyle intervention: Results from the action for health in diabetes (Look AHEAD) clinical trial

Rebecca H. Neiberg; Jared J. Rejeski; William B. Applegate; Jeanne M. Clark; William C. Knowler; George A. Bray; Mark A. Espeland; Lawrence J. Cheskin

doi:10.2337/diaclin.33.4.181

Self-reported gastrointestinal symptoms in type 2 diabetes improve with an intensive lifestyle intervention: Results from the action for health in diabetes (Look AHEAD) clinical trial

Rebecca H. Neiberg, Jared J. Rejeski, William B. Applegate, Jeanne M. Clark, William C. Knowler, George A. Bray, Mark A. Espeland, Lawrence J. Cheskin

School of Medicine

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

This article reports on an investigation of whether an intensive lifestyle intervention (ILI) would reduce gastrointestinal symptoms over 4 years of follow-up for participants in the Action for Health in Diabetes (Look AHEAD) trial compared to a diabetes support and education (DSE) group. Look AHEAD is a randomized, multicenter trial comparing overweight and obese adults with type 2 diabetes treated with ILI versus DSE. ILI, and weight loss in general, had beneficial effects on gastrointestinal (GI) symptoms, with some variability in the strength of the effect depending on the specific symptom and time course. Potential modifiers were analyzed, yet ILI retained an association with improvement in GI symptoms.

Original language	English (US)
Pages (from-to)	181-188
Number of pages	8
Journal	Clinical Diabetes
Volume	33
Issue number	4
DOIs	https://doi.org/10.2337/diaclin.33.4.181
State	Published - Sep 1 2015

ASJC Scopus subject areas

Internal Medicine
Endocrinology, Diabetes and Metabolism

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10.2337/diaclin.33.4.181

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Neiberg, R. H., Rejeski, J. J., Applegate, W. B., Clark, J. M., Knowler, W. C., Bray, G. A., Espeland, M. A., & Cheskin, L. J. (2015). Self-reported gastrointestinal symptoms in type 2 diabetes improve with an intensive lifestyle intervention: Results from the action for health in diabetes (Look AHEAD) clinical trial. Clinical Diabetes, 33(4), 181-188. https://doi.org/10.2337/diaclin.33.4.181

Self-reported gastrointestinal symptoms in type 2 diabetes improve with an intensive lifestyle intervention: Results from the action for health in diabetes (Look AHEAD) clinical trial. / Neiberg, Rebecca H.; Rejeski, Jared J.; Applegate, William B. et al.
In: Clinical Diabetes, Vol. 33, No. 4, 01.09.2015, p. 181-188.

Research output: Contribution to journal › Article › peer-review

Neiberg, RH, Rejeski, JJ, Applegate, WB, Clark, JM, Knowler, WC, Bray, GA, Espeland, MA & Cheskin, LJ 2015, 'Self-reported gastrointestinal symptoms in type 2 diabetes improve with an intensive lifestyle intervention: Results from the action for health in diabetes (Look AHEAD) clinical trial', Clinical Diabetes, vol. 33, no. 4, pp. 181-188. https://doi.org/10.2337/diaclin.33.4.181

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Self-reported gastrointestinal symptoms in type 2 diabetes improve with an intensive lifestyle intervention: Results from the action for health in diabetes (Look AHEAD) clinical trial

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