Self-report of cognitive impairment and mini-mental state examination performance in PRKN, LRRK2, and GBA carriers with early onset Parkinson's disease

Roy N. Alcalay; Helen Mejia-Santana; Ming X. Tang; Brian Rakitin; Llency Rosado; Barbara Ross; Miguel Verbitsky; Sergey Kisselev; Elan D. Louis; Cynthia L. Comella; Amy Colcher; Danna Jennings; Martha A. Nance; Susan Bressman; William K. Scott; Caroline Tanner; Susan F. Mickel; Howard F. Andrews; Cheryl H. Waters; Stanley Fahn; Lucien J. Cote; Steven J. Frucht; Blair Ford; Michael Rezak; Kevin Novak; Joseph H. Friedman; Ronald Pfeiffer; Laura Marsh; Bradley Hiner; Andrew Siderowf; Ruth Ottman; Lorraine N. Clark; Karen S. Marder; Elise Caccappolo

doi:10.1080/13803390903521018

Self-report of cognitive impairment and mini-mental state examination performance in PRKN, LRRK2, and GBA carriers with early onset Parkinson's disease

Roy N. Alcalay, Helen Mejia-Santana, Ming X. Tang, Brian Rakitin, Llency Rosado, Barbara Ross, Miguel Verbitsky, Sergey Kisselev, Elan D. Louis, Cynthia L. Comella, Amy Colcher, Danna Jennings, Martha A. Nance, Susan Bressman, William K. Scott, Caroline Tanner, Susan F. Mickel, Howard F. Andrews, Cheryl H. Waters, Stanley FahnLucien J. Cote, Steven J. Frucht, Blair Ford, Michael Rezak, Kevin Novak, Joseph H. Friedman, Ronald Pfeiffer, Laura Marsh, Bradley Hiner, Andrew Siderowf, Ruth Ottman, Lorraine N. Clark, Karen S. Marder, Elise Caccappolo

School of Medicine

Research output: Contribution to journal › Article › peer-review

37 Scopus citations

Abstract

While little is known about risk factors for cognitive impairment in early onset Parkinson disease (EOPD), postmortem studies have shown an association between dementia with Lewy bodies (DLB) and glucocerebrosidase (GBA) mutation. We compared Mini-Mental State Examination (MMSE) performance and self-reported cognitive impairment in 699 EOPD participants genotyped for mutations in parkin (PRKN), leucine-rich repeat kinase-2 (LRRK2), and GBA. Logistic regression was used to assess the association between reported cognitive impairment and MMSE score, as well as between GBA group membership and self-reported impairment and MMSE. GBA carriers reported more impairment, but MMSE performance did not differ among genetic groups. Detailed neuropsychological testing is required to explore the association between cognitive impairment and GBA mutations.

Original language	English (US)
Pages (from-to)	775-779
Number of pages	5
Journal	Journal of Clinical and Experimental Neuropsychology
Volume	32
Issue number	7
DOIs	https://doi.org/10.1080/13803390903521018
State	Published - Aug 2010

Keywords

Cognition
Genetics
Glucocerebrosidase
Leucine-rich repeat kinase-2
Mini-mental state examination
Parkin
Parkinson

ASJC Scopus subject areas

Clinical Neurology
Neurology
Clinical Psychology
Medicine(all)

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10.1080/13803390903521018

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Alcalay, R. N., Mejia-Santana, H., Tang, M. X., Rakitin, B., Rosado, L., Ross, B., Verbitsky, M., Kisselev, S., Louis, E. D., Comella, C. L., Colcher, A., Jennings, D., Nance, M. A., Bressman, S., Scott, W. K., Tanner, C., Mickel, S. F., Andrews, H. F., Waters, C. H., ... Caccappolo, E. (2010). Self-report of cognitive impairment and mini-mental state examination performance in PRKN, LRRK2, and GBA carriers with early onset Parkinson's disease. Journal of Clinical and Experimental Neuropsychology, 32(7), 775-779. https://doi.org/10.1080/13803390903521018

Self-report of cognitive impairment and mini-mental state examination performance in PRKN, LRRK2, and GBA carriers with early onset Parkinson's disease. / Alcalay, Roy N.; Mejia-Santana, Helen; Tang, Ming X. et al.
In: Journal of Clinical and Experimental Neuropsychology, Vol. 32, No. 7, 08.2010, p. 775-779.

Research output: Contribution to journal › Article › peer-review

Alcalay, RN, Mejia-Santana, H, Tang, MX, Rakitin, B, Rosado, L, Ross, B, Verbitsky, M, Kisselev, S, Louis, ED, Comella, CL, Colcher, A, Jennings, D, Nance, MA, Bressman, S, Scott, WK, Tanner, C, Mickel, SF, Andrews, HF, Waters, CH, Fahn, S, Cote, LJ, Frucht, SJ, Ford, B, Rezak, M, Novak, K, Friedman, JH, Pfeiffer, R, Marsh, L, Hiner, B, Siderowf, A, Ottman, R, Clark, LN, Marder, KS & Caccappolo, E 2010, 'Self-report of cognitive impairment and mini-mental state examination performance in PRKN, LRRK2, and GBA carriers with early onset Parkinson's disease', Journal of Clinical and Experimental Neuropsychology, vol. 32, no. 7, pp. 775-779. https://doi.org/10.1080/13803390903521018

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abstract = "While little is known about risk factors for cognitive impairment in early onset Parkinson disease (EOPD), postmortem studies have shown an association between dementia with Lewy bodies (DLB) and glucocerebrosidase (GBA) mutation. We compared Mini-Mental State Examination (MMSE) performance and self-reported cognitive impairment in 699 EOPD participants genotyped for mutations in parkin (PRKN), leucine-rich repeat kinase-2 (LRRK2), and GBA. Logistic regression was used to assess the association between reported cognitive impairment and MMSE score, as well as between GBA group membership and self-reported impairment and MMSE. GBA carriers reported more impairment, but MMSE performance did not differ among genetic groups. Detailed neuropsychological testing is required to explore the association between cognitive impairment and GBA mutations.",

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AU - Verbitsky, Miguel

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AU - Hiner, Bradley

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Self-report of cognitive impairment and mini-mental state examination performance in PRKN, LRRK2, and GBA carriers with early onset Parkinson's disease

Abstract

Keywords

ASJC Scopus subject areas

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