Self-expandable and highly flexible nitinol stent: Immediate and long-term results in dogs

Ehud Grenadier, Rona Shofti, Mordechai Beyar, Haim Lichtig, Daniel Mordechowitz, Oren Globerman, Walter Markiewicz, Rafael Beyar

Research output: Contribution to journalArticlepeer-review

35 Scopus citations


We sought to investigate the acute and long-term patency rates and the histologic response of coronary arteries to a self-expandable nitinol coil stent. Twenty-two stents were implanted. Angiographic patency was demonstrated acutely in all but one dog, in which the stent was released in a small branch (1 mm); mismatch in stent-to-artery diameters resulted in vessel closure. Two dogs died from anesthesia overdose and two from bleeding within 24 hours. All dogs were treated with aspirin (80 mg/day) and warfarin (2.5 mg/day) for up to 1 month. Sixteen dogs were monitored for 1 to 2 weeks, 1 month, 3 months, 6 months, and 1 year and underwent subsequent angiography and histopathologic examination. Angiographic artery dimensions measured immediately after stent implantation (2.72 ± 0.4 mm) did not differ from those noted at follow-up (2.68 ± 0.44 mm, p not significant). Histologic examination showed outward stent pressure compressing the internal elastic membrane and media in most cases. Intimal hyperplasia started at 2 weeks and was most apparent at 3 and 6 months. Mean intimal thickness was 30.7 ± 10.9μ, 141.8 ± 105.4μ, 227.1 ± 104.1μ, 211.8 ± 99.1μ, and 170.1 ± 42.7μ at 1 to 2 weeks and 1, 3, 6 and 12 months, respectively. Therefore the nitinol self-expandable stent provokes a moderate cellular proliferative response that reaches its maximum in 3 to 6 months without further progression.

Original languageEnglish (US)
Pages (from-to)870-878
Number of pages9
JournalAmerican Heart Journal
Issue number5
StatePublished - 1994
Externally publishedYes

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


Dive into the research topics of 'Self-expandable and highly flexible nitinol stent: Immediate and long-term results in dogs'. Together they form a unique fingerprint.

Cite this