TY - JOUR
T1 - Self-assembled three dimensional radio frequency (RF) shielded containers for cell encapsulation.
AU - Gimi, Barjor
AU - Leong, Timothy
AU - Gu, Zhiyong
AU - Yang, Michael
AU - Artemov, Dmitri
AU - Bhujwalla, Zaver M.
AU - Gracias, David H.
N1 - Funding Information:
This research was supported in part by the National Institutes of Health (NIH P50 CA 103175). We thank Dr. Richard L. Magin for useful discussions and Dr. Piotr Wal-czak for help with loading the containers with cells.
PY - 2005/12
Y1 - 2005/12
N2 - This paper describes the construction of three dimensional (3D) encapsulation devices in large numbers, using a novel self-assembling strategy characterized by high mechanical stability, controlled porosity, extreme miniaturization, high reproducibility and the possibility of integrating sensing and actuating electromechanical modules. We demonstrated encapsulation of microbeads and cells within the containers, thereby demonstrating one possible application in cell encapsulation therapy. Magnetic resonance (MR) images of the containers in fluidic media suggest radio frequency (RF) shielding and a susceptibility effect, providing characteristic hypointensity within the container, thereby allowing the containers to be easily detected. This demonstration is the first step toward the design of 3D, micropatterned, non-invasively trackable, encapsulation devices.
AB - This paper describes the construction of three dimensional (3D) encapsulation devices in large numbers, using a novel self-assembling strategy characterized by high mechanical stability, controlled porosity, extreme miniaturization, high reproducibility and the possibility of integrating sensing and actuating electromechanical modules. We demonstrated encapsulation of microbeads and cells within the containers, thereby demonstrating one possible application in cell encapsulation therapy. Magnetic resonance (MR) images of the containers in fluidic media suggest radio frequency (RF) shielding and a susceptibility effect, providing characteristic hypointensity within the container, thereby allowing the containers to be easily detected. This demonstration is the first step toward the design of 3D, micropatterned, non-invasively trackable, encapsulation devices.
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U2 - 10.1007/s10544-005-6076-9
DO - 10.1007/s10544-005-6076-9
M3 - Article
C2 - 16404512
AN - SCOPUS:33645218977
SN - 1387-2176
VL - 7
SP - 341
EP - 345
JO - Biomedical microdevices
JF - Biomedical microdevices
IS - 4
ER -