Selectivity to amyloid- precursor protein cleavage provides hope against Alzheimer's

Taisuke Tomita; Philip C. Wong

doi:10.1186/alzrt66

Selectivity to amyloid- precursor protein cleavage provides hope against Alzheimer's

Taisuke Tomita, Philip C. Wong

School of Medicine

Research output: Contribution to journal › Review article › peer-review

1 Scopus citations

Abstract

Toward development of a safe and effective treatment for Alzheimer's disease, Elan Pharmaceuticals reported a novel -secretase inhibitor that specifically targets the cleavage of amyloid- precursor protein, opening the way to design of substrate-specific -secretase inhibitors that would reduce the amyloid burden without significant adverse events.

Original language	English (US)
Article number	7
Journal	Alzheimer's Research and Therapy
Volume	3
Issue number	2
DOIs	https://doi.org/10.1186/alzrt66
State	Published - 2011

ASJC Scopus subject areas

Neurology
Clinical Neurology
Cognitive Neuroscience

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title = "Selectivity to amyloid- precursor protein cleavage provides hope against Alzheimer's",

abstract = "Toward development of a safe and effective treatment for Alzheimer's disease, Elan Pharmaceuticals reported a novel -secretase inhibitor that specifically targets the cleavage of amyloid- precursor protein, opening the way to design of substrate-specific -secretase inhibitors that would reduce the amyloid burden without significant adverse events.",

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Selectivity to amyloid- precursor protein cleavage provides hope against Alzheimer's

Abstract

ASJC Scopus subject areas

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