Selective serotonin reuptake inhibitors for children and adolescents.

E. A. Kastelic, M. J. Labellarte, M. A. Riddle

Research output: Contribution to journalReview articlepeer-review

16 Scopus citations


The controlled studies of selective serotonin reuptake inhibitors (SSRIs) in pediatric psychopharmacology research lag behind the controlled studies of SSRIs in adults. As a result, widespread use of SSRIs in the treatment of child and adolescent psychiatric disorders is in stark contrast to the paucity of research data. Recent changes in the research climate (including support from the National Institute of Mental Health, the Food and Drug Administration, and industry) have encouraged well-designed SSRI studies in pediatric psychopharmacology, and will ultimately provide needed information to guide treatment. This paper reviews the best available data from pediatric SSRI trials, including 10 double-blind placebo-controlled trials, and two abstracts of open-label continuation studies of SSRIs associated with large pediatric efficacy studies. Adverse events (AEs) of SSRIs in children and adolescents are discussed in reference to available pediatric studies. Recent pharmacokinetic studies of SSRIs in children and adolescents are reviewed. Future SSRI research strategies are also discussed.

Original languageEnglish (US)
Pages (from-to)117-123
Number of pages7
JournalCurrent psychiatry reports
Issue number2
StatePublished - Apr 2000

ASJC Scopus subject areas

  • Psychiatry and Mental health


Dive into the research topics of 'Selective serotonin reuptake inhibitors for children and adolescents.'. Together they form a unique fingerprint.

Cite this