Selective Persulfide Detection Reveals Evolutionarily Conserved Antiaging Effects of S-Sulfhydration

Jasmina Zivanovic, Emilia Kouroussis, Joshua B. Kohl, Bikash Adhikari, Biljana Bursac, Sonia Schott-Roux, Dunja Petrovic, Jan Lj Miljkovic, Daniel Thomas-Lopez, Youngeun Jung, Marko Miler, Sarah Mitchell, Verica Milosevic, Jose Eduardo Gomes, Moran Benhar, Bruno Gonzales-Zorn, Ivana Ivanovic-Burmazovic, Roberta Torregrossa, James R. Mitchell, Matthew WhitemanGuenter Schwarz, Solomon H. Snyder, Bindu D. Paul, Kate S. Carroll, Milos R. Filipovic

Research output: Contribution to journalArticlepeer-review

58 Scopus citations


Zivanovic et al. develop a robust method for chemoselective persulfide labeling using dimedone-based probes to show that persulfidation is an evolutionarily conserved post-translational modification used by the cells to protect proteins from overoxidation caused by different stressors. Higher persulfidation levels, caused by pharmacological or dietary interventions, lead to better resistance to oxidative stress and longer life.

Original languageEnglish (US)
Pages (from-to)1152-1170.e13
JournalCell Metabolism
Issue number6
StatePublished - Dec 3 2019


  • aging
  • calorie restriction
  • hydrogen peroxide
  • hydrogen sulfide
  • protein persulfidation
  • redox signaling
  • sulfenylation
  • sulfinylation
  • sulfonylation

ASJC Scopus subject areas

  • Physiology
  • Molecular Biology
  • Cell Biology


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