Transfusion-induced iron overload is an often fatal consequence of chronic transfusion for severe, refractory anemia. Children with thalassemia major represent the largest affected group, but transfusional siderosis complicates a variety of other disorders. Blood cell separators have been adapted to collect young red cells (YRBC) for transfusion support of these patients. Red cell units harvested by this technique have an average estimated mean cell age of 30 days and could theoretically halve the transfusion requirement for transfusion dependent patients. Expense and technical difficulty have limited application of the cell separator procedure. Preliminary reports of methods which can isolate YRBC from single donor units of blood suggest that cell washers or discontinuous gradients might provide more practical approaches. Little clinical information is available. A treatment schedule combining YRBC transfusion with effective iron chelation could retard the onset of transfusion induced hemochromatosis.
|Number of pages
|Plasma Therapy and Transfusion Technology
|Published - 1981
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