TY - JOUR
T1 - Selective Immunotoxic Lesions of Basal Forebrain Cholinergic Cells
T2 - Effects on Learning and Memory in Rats
AU - Baxter, Mark G.
AU - Bucci, David J.
AU - Gorman, Linda K.
AU - Wiley, Ronald G.
AU - Gallagher, Michela
PY - 1995/8
Y1 - 1995/8
N2 - Male Long-Evans rats were given injections of either 192 IgG-saporin, an apparently selective toxin for basal forebrain cholinergic neurons (LES), or vehicle (CON) into either the medial septum and vertical limb of the diagonal band (MS/VDB) or bilaterally into the nucleus basalis magnocellularis and substantia innominata (nBM/SI). Place discrimination in the Morris water maze assessed spatial learning, and a trial-unique matching-to-place task in the water maze assessed memory for place information over varying delays. MS/VDB-LES and nBM/SI-LES rats were not impaired relative to CON rats in acquisition of the place discrimination, but were mildly impaired relative to CON rats in performance of the memory task even at the shortest delay, suggesting a nonmnemonic deficit. These results contrast with effects of less selective lesions, which have been taken to support a role for basal forebrain cholinergic neurons in learning and memory.
AB - Male Long-Evans rats were given injections of either 192 IgG-saporin, an apparently selective toxin for basal forebrain cholinergic neurons (LES), or vehicle (CON) into either the medial septum and vertical limb of the diagonal band (MS/VDB) or bilaterally into the nucleus basalis magnocellularis and substantia innominata (nBM/SI). Place discrimination in the Morris water maze assessed spatial learning, and a trial-unique matching-to-place task in the water maze assessed memory for place information over varying delays. MS/VDB-LES and nBM/SI-LES rats were not impaired relative to CON rats in acquisition of the place discrimination, but were mildly impaired relative to CON rats in performance of the memory task even at the shortest delay, suggesting a nonmnemonic deficit. These results contrast with effects of less selective lesions, which have been taken to support a role for basal forebrain cholinergic neurons in learning and memory.
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U2 - 10.1037/0735-7044.109.4.714
DO - 10.1037/0735-7044.109.4.714
M3 - Article
C2 - 7576215
AN - SCOPUS:0029131221
SN - 0735-7044
VL - 109
SP - 714
EP - 722
JO - Behavioral Neuroscience
JF - Behavioral Neuroscience
IS - 4
ER -