TY - JOUR
T1 - Selective and Nonselective Monoamine Oxidase Inhibitors
T2 - Behavioral Disturbances During Their Administration to Depressed Patients
AU - Pickar, David
AU - Murphy, Dennis L.
AU - Cohen, Robert M.
AU - Campbell, Iain C.
AU - Lipper, Steven
PY - 1982
Y1 - 1982
N2 - The occurrence of behavioral disturbances during fourweek treatment of depressed patients with the nonselective monoamine oxidase (MAO) inhibitor, phenelzine sulfate (N = 14), the selective MAO-type A inhibitor, clorgyline (N = 12), and the partially selective MAO-type B inhibitor, pargyline hydrochloride (N = 13), was studied. Behavioral disturbances were encountered during treatment with each of the MAO-inhibiting drugs, with an overall incidence of 15% (six of 39 patients). All but one episode met criteria for mania or hypomania. Patients with bipolar illness experienced significantly greater incidences of behavioral disturbances in comparison with patients with unipolar illness (35.3% v 4.5%, respectively). The earliest latency to onset of a behavioral disturbance was 18 days, whereas the mean latencies were 22 to 26 days. Episodes of hypomania were observed after discontinuation of drug treatment in individual patients with unipolar and bipolar illness. Repeated MAO-inhibitor treatment, as part of a crossover study of clorgyline and pargyline, produced an increased severity of behavioral disturbances and a significantly shortened latency to onset.
AB - The occurrence of behavioral disturbances during fourweek treatment of depressed patients with the nonselective monoamine oxidase (MAO) inhibitor, phenelzine sulfate (N = 14), the selective MAO-type A inhibitor, clorgyline (N = 12), and the partially selective MAO-type B inhibitor, pargyline hydrochloride (N = 13), was studied. Behavioral disturbances were encountered during treatment with each of the MAO-inhibiting drugs, with an overall incidence of 15% (six of 39 patients). All but one episode met criteria for mania or hypomania. Patients with bipolar illness experienced significantly greater incidences of behavioral disturbances in comparison with patients with unipolar illness (35.3% v 4.5%, respectively). The earliest latency to onset of a behavioral disturbance was 18 days, whereas the mean latencies were 22 to 26 days. Episodes of hypomania were observed after discontinuation of drug treatment in individual patients with unipolar and bipolar illness. Repeated MAO-inhibitor treatment, as part of a crossover study of clorgyline and pargyline, produced an increased severity of behavioral disturbances and a significantly shortened latency to onset.
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U2 - 10.1001/archpsyc.1982.04290050023006
DO - 10.1001/archpsyc.1982.04290050023006
M3 - Article
C2 - 7092487
AN - SCOPUS:0020066264
SN - 0003-990X
VL - 39
SP - 535
EP - 540
JO - Archives of General Psychiatry
JF - Archives of General Psychiatry
IS - 5
ER -