Selective activation of human mast cells by general anesthetics

C. Stellato, V. Casolaro, A. Ciccarelli, G. de Crescenzo, V. Patella, G. Marone

Research output: Contribution to journalArticlepeer-review


We investigated the in vitro effects of increasing concentrations of three general anesthetics commonly used in clinical practice, i.e., ketamine (10-6-10-3M), thiopentone (10-5-8×10-4M) and propofol (5-70 μg/ml), on histamine release (HR) from human peripheral blood basophils and mast cells isolated from lung parenchyma (HLMC) and skin tissues (HSMC). None of the drugs induced HR from basophils. Ketamine caused HR from HLMC (p

Original languageEnglish (US)
JournalAgents and Actions
Issue number2 Supplement
StatePublished - Jun 1992
Externally publishedYes

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology (medical)


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