Purpose. A Phase I/II clinical trial of photodynamic therapy (PDT) using liposomal BPD for subfoveal choroidal neovascularization (CNV) has been conducted to evaluate ocular safety, proof of principle, and preliminary dose-ranging. Observations from selected angiograms pre- and post-PDT will be presented. Methods. Standardized fluorescein angiography (FA) was used to calculate the irradiation area and location, and post-treatment FA was graded for CNV closure. In 5 patients, BPD angiography (by infusion) was also performed. Video fundus imaging recorded the irradiation. Results. Pre-treatment FA demonstrated classic subfoveal CNV +/- occult CNV. BPD angiography demonstrated fluorescence in normal choroidal and retinal vessels in the first 10 mins. of dye infusion, and delineated the CNV. Post-treatment FA typically demonstrated closure of classic CNV at 1 week, with hypofluorescence corresponding to the irradiated area. At 4 weeks, the hypofluorescent zone was not seen, and the classic CNV was partially perfused. Retinal arteriole and venule closure was noted in a patient at 1 week, suggesting a dose-limiting side effect Conclusions. FA of patients treated with PDT demonstrated early CNV closure, with subsequent reperfusion of a portion of the neovasculature. BPD angiography may be useful to demonstrate the selective accumulation of dye in CNV.
|Investigative Ophthalmology and Visual Science
|Published - Feb 15 1996
ASJC Scopus subject areas
- Sensory Systems
- Cellular and Molecular Neuroscience