Segregation analysis of blood pressure and body mass index in a rural US community

Swapan K. Nath; Aravinda Chakravarti; Chien Hsiun Chen; Richard Cooper; Alan Weder; Nicholas J. Schork

doi:10.1353/hub.2002.0010

Segregation analysis of blood pressure and body mass index in a rural US community

Swapan K. Nath, Aravinda Chakravarti, Chien Hsiun Chen, Richard Cooper, Alan Weder, Nicholas J. Schork

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

To assess evidence for a gene with large effect on systolic blood pressure (SBP), diastolic blood pressure (DBP), and body mass index (BMI), we conducted segregation analyses on 261 nuclear families collected from a rural Caucasian community in Michigan. The families were ascertained through a hypertensive proband. Each phenotype was adjusted for significant covariate effects (e.g., gender and age). We used class D regressive models to conduct the segregation analyses. Our analysis results support the segregation of a major gene for BMI, but not for SBP or DBP. A recessive locus effect provided the best explanation for BMI where ∼43% of the variance of BMI was due to this gene.

Original language	English (US)
Pages (from-to)	11-23
Number of pages	13
Journal	Human Biology
Volume	74
Issue number	1
DOIs	https://doi.org/10.1353/hub.2002.0010
State	Published - 2002
Externally published	Yes

Keywords

Blood pressure
Body mass index
Commingling analysis
Segregation analysis

ASJC Scopus subject areas

Ecology, Evolution, Behavior and Systematics
Genetics
Genetics(clinical)

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abstract = "To assess evidence for a gene with large effect on systolic blood pressure (SBP), diastolic blood pressure (DBP), and body mass index (BMI), we conducted segregation analyses on 261 nuclear families collected from a rural Caucasian community in Michigan. The families were ascertained through a hypertensive proband. Each phenotype was adjusted for significant covariate effects (e.g., gender and age). We used class D regressive models to conduct the segregation analyses. Our analysis results support the segregation of a major gene for BMI, but not for SBP or DBP. A recessive locus effect provided the best explanation for BMI where ∼43% of the variance of BMI was due to this gene.",

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AU - Chakravarti, Aravinda

AU - Chen, Chien Hsiun

AU - Cooper, Richard

AU - Weder, Alan

AU - Schork, Nicholas J.

PY - 2002

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AB - To assess evidence for a gene with large effect on systolic blood pressure (SBP), diastolic blood pressure (DBP), and body mass index (BMI), we conducted segregation analyses on 261 nuclear families collected from a rural Caucasian community in Michigan. The families were ascertained through a hypertensive proband. Each phenotype was adjusted for significant covariate effects (e.g., gender and age). We used class D regressive models to conduct the segregation analyses. Our analysis results support the segregation of a major gene for BMI, but not for SBP or DBP. A recessive locus effect provided the best explanation for BMI where ∼43% of the variance of BMI was due to this gene.

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KW - Commingling analysis

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Segregation analysis of blood pressure and body mass index in a rural US community

Abstract

Keywords

ASJC Scopus subject areas

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