Segregation analysis of blood pressure and body mass index in a rural US community

Swapan K. Nath, Aravinda Chakravarti, Chien Hsiun Chen, Richard Cooper, Alan Weder, Nicholas J. Schork

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


To assess evidence for a gene with large effect on systolic blood pressure (SBP), diastolic blood pressure (DBP), and body mass index (BMI), we conducted segregation analyses on 261 nuclear families collected from a rural Caucasian community in Michigan. The families were ascertained through a hypertensive proband. Each phenotype was adjusted for significant covariate effects (e.g., gender and age). We used class D regressive models to conduct the segregation analyses. Our analysis results support the segregation of a major gene for BMI, but not for SBP or DBP. A recessive locus effect provided the best explanation for BMI where ∼43% of the variance of BMI was due to this gene.

Original languageEnglish (US)
Pages (from-to)11-23
Number of pages13
JournalHuman Biology
Issue number1
StatePublished - 2002
Externally publishedYes


  • Blood pressure
  • Body mass index
  • Commingling analysis
  • Segregation analysis

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Genetics
  • Genetics(clinical)


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