Segmental cholestasis drives global hepatic fibrosis: lessons from the sBDL model in weaned rats

Hee Seong Jang; Chhinder P. Sodhi

doi:10.1038/s41390-025-04526-8

Segmental cholestasis drives global hepatic fibrosis: lessons from the sBDL model in weaned rats

School of Medicine

Research output: Contribution to journal › Comment/debate › peer-review

Abstract

Impact statement: This commentary provides a detailed analysis of Gonçalves et al.’s research paper, “Key genes and histopathological alterations in hepatic fibrogenesis after segmental cholestasis in weaned rats.¹” It emphasizes how segmental cholestasis caused by selective bile duct ligation in young rats leads to extensive hepatic fibrogenesis, affecting both obstructed and non-obstructed liver lobes—similar to pediatric cholangiopathies like biliary atresia and post-transplant strictures in children. It not only illustrates regional hepatic disease patterns but also offers a valid preclinical platform for testing antifibrotic treatments.

Original language	English (US)
Pages (from-to)	1248-1249
Number of pages	2
Journal	Pediatric research
Volume	99
Issue number	4
DOIs	https://doi.org/10.1038/s41390-025-04526-8
State	Published - Mar 2026

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health

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title = "Segmental cholestasis drives global hepatic fibrosis: lessons from the sBDL model in weaned rats",

abstract = "Impact statement: This commentary provides a detailed analysis of Gon{\c c}alves et al.{\textquoteright}s research paper, {\textquotedblleft}Key genes and histopathological alterations in hepatic fibrogenesis after segmental cholestasis in weaned rats.1{\textquotedblright} It emphasizes how segmental cholestasis caused by selective bile duct ligation in young rats leads to extensive hepatic fibrogenesis, affecting both obstructed and non-obstructed liver lobes{\textemdash}similar to pediatric cholangiopathies like biliary atresia and post-transplant strictures in children. It not only illustrates regional hepatic disease patterns but also offers a valid preclinical platform for testing antifibrotic treatments.",

author = "Jang, \{Hee Seong\} and Sodhi, \{Chhinder P.\}",

note = "Publisher Copyright: {\textcopyright} The Author(s), under exclusive licence to the International Pediatric Research Foundation, Inc 2025.",

year = "2026",

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doi = "10.1038/s41390-025-04526-8",

language = "English (US)",

volume = "99",

pages = "1248--1249",

journal = "Pediatric research",

issn = "0031-3998",

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TY - JOUR

T1 - Segmental cholestasis drives global hepatic fibrosis

T2 - lessons from the sBDL model in weaned rats

AU - Jang, Hee Seong

AU - Sodhi, Chhinder P.

N1 - Publisher Copyright: © The Author(s), under exclusive licence to the International Pediatric Research Foundation, Inc 2025.

PY - 2026/3

Y1 - 2026/3

N2 - Impact statement: This commentary provides a detailed analysis of Gonçalves et al.’s research paper, “Key genes and histopathological alterations in hepatic fibrogenesis after segmental cholestasis in weaned rats.1” It emphasizes how segmental cholestasis caused by selective bile duct ligation in young rats leads to extensive hepatic fibrogenesis, affecting both obstructed and non-obstructed liver lobes—similar to pediatric cholangiopathies like biliary atresia and post-transplant strictures in children. It not only illustrates regional hepatic disease patterns but also offers a valid preclinical platform for testing antifibrotic treatments.

AB - Impact statement: This commentary provides a detailed analysis of Gonçalves et al.’s research paper, “Key genes and histopathological alterations in hepatic fibrogenesis after segmental cholestasis in weaned rats.1” It emphasizes how segmental cholestasis caused by selective bile duct ligation in young rats leads to extensive hepatic fibrogenesis, affecting both obstructed and non-obstructed liver lobes—similar to pediatric cholangiopathies like biliary atresia and post-transplant strictures in children. It not only illustrates regional hepatic disease patterns but also offers a valid preclinical platform for testing antifibrotic treatments.

UR - https://www.scopus.com/pages/publications/105019599164

UR - https://www.scopus.com/pages/publications/105019599164#tab=citedBy

U2 - 10.1038/s41390-025-04526-8

DO - 10.1038/s41390-025-04526-8

M3 - Comment/debate

C2 - 41125961

AN - SCOPUS:105019599164

SN - 0031-3998

VL - 99

SP - 1248

EP - 1249

JO - Pediatric research

JF - Pediatric research

IS - 4

ER -

Segmental cholestasis drives global hepatic fibrosis: lessons from the sBDL model in weaned rats

Abstract

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