Secretion of proliferin

Se Jin Lee; Daniel Nathans

doi:10.1210/endo-120-1-208

Secretion of proliferin

Se Jin Lee, Daniel Nathans

School of Medicine

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

Proliferin (PLF) is a member of the PRL-GH family whose mRNA has been detected in proliferating mouse cells in culture and in mouse placenta. Suspensions of murine placental tissue have been shown to produce PLF detectable by immunoprecipitation. Here we report that PLF is secreted as a heterogeneous glycoprotein by growing mouse cell lines and placental tissue and that the first 29 amino acids of the preprotein serve as a signal peptide. Placental PLF is immunologically distinguishable from the 2 previously described mouse placental lactogens.

Original language	English (US)
Pages (from-to)	208-213
Number of pages	6
Journal	Endocrinology
Volume	120
Issue number	1
DOIs	https://doi.org/10.1210/endo-120-1-208
State	Published - Jan 1987

ASJC Scopus subject areas

Endocrinology

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10.1210/endo-120-1-208

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abstract = "Proliferin (PLF) is a member of the PRL-GH family whose mRNA has been detected in proliferating mouse cells in culture and in mouse placenta. Suspensions of murine placental tissue have been shown to produce PLF detectable by immunoprecipitation. Here we report that PLF is secreted as a heterogeneous glycoprotein by growing mouse cell lines and placental tissue and that the first 29 amino acids of the preprotein serve as a signal peptide. Placental PLF is immunologically distinguishable from the 2 previously described mouse placental lactogens.",

author = "Lee, {Se Jin} and Daniel Nathans",

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AB - Proliferin (PLF) is a member of the PRL-GH family whose mRNA has been detected in proliferating mouse cells in culture and in mouse placenta. Suspensions of murine placental tissue have been shown to produce PLF detectable by immunoprecipitation. Here we report that PLF is secreted as a heterogeneous glycoprotein by growing mouse cell lines and placental tissue and that the first 29 amino acids of the preprotein serve as a signal peptide. Placental PLF is immunologically distinguishable from the 2 previously described mouse placental lactogens.

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Secretion of proliferin

Abstract

ASJC Scopus subject areas

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