Secretion of proliferin

Se Jin Lee, Daniel Nathans

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


Proliferin (PLF) is a member of the PRL-GH family whose mRNA has been detected in proliferating mouse cells in culture and in mouse placenta. Suspensions of murine placental tissue have been shown to produce PLF detectable by immunoprecipitation. Here we report that PLF is secreted as a heterogeneous glycoprotein by growing mouse cell lines and placental tissue and that the first 29 amino acids of the preprotein serve as a signal peptide. Placental PLF is immunologically distinguishable from the 2 previously described mouse placental lactogens.

Original languageEnglish (US)
Pages (from-to)208-213
Number of pages6
Issue number1
StatePublished - Jan 1987

ASJC Scopus subject areas

  • Endocrinology


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