TY - JOUR
T1 - Secretin, a stimulus for duodenal and pancreatic "gastrin" release
T2 - Possible pathogenetic significance in Zollinger-Ellison (ZE) syndrome
AU - Eckhauser, Frederic E.
AU - Vinik, Aaron I.
AU - McLeod, Michael
AU - Porter-Fink, Vicki
AU - Fiddian-Green, Richard G.
PY - 1980/4
Y1 - 1980/4
N2 - Ex vivo hemoperfused pancreaticoduodenal preparations from dogs have been used to study intraluminal and circulatory patterns of release of immunoreactive gastrin under basal conditions and after secretin stimulation. Bidirectional release of immunoreactive gastrin was maximal at 3 U/min secretin infusion, and release into pancreatic and duodenal juice exceeded that into portal venous blood. Molecular sieving chromatography of peptides with gastrin-like immunoreactivity recovered from duodenal and pancreatic juice indicated a single species of a molecular size equivalent to CCK8 and smaller than minigastrin (G-14). The exact identity has not been defined. This study demonstrates that secretin stimulates release of gastrin-like peptides into blood and lumen of extra-antral gastrin-producing tissues in the dog. Unidirectional gastrin release patterns from gastrinoma tissue may explain the paradoxical increase in plasma gastrin levels in response to secretin in patients with gastrinomas (Zollinger-Ellison syndrome).
AB - Ex vivo hemoperfused pancreaticoduodenal preparations from dogs have been used to study intraluminal and circulatory patterns of release of immunoreactive gastrin under basal conditions and after secretin stimulation. Bidirectional release of immunoreactive gastrin was maximal at 3 U/min secretin infusion, and release into pancreatic and duodenal juice exceeded that into portal venous blood. Molecular sieving chromatography of peptides with gastrin-like immunoreactivity recovered from duodenal and pancreatic juice indicated a single species of a molecular size equivalent to CCK8 and smaller than minigastrin (G-14). The exact identity has not been defined. This study demonstrates that secretin stimulates release of gastrin-like peptides into blood and lumen of extra-antral gastrin-producing tissues in the dog. Unidirectional gastrin release patterns from gastrinoma tissue may explain the paradoxical increase in plasma gastrin levels in response to secretin in patients with gastrinomas (Zollinger-Ellison syndrome).
UR - http://www.scopus.com/inward/record.url?scp=0018861872&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0018861872&partnerID=8YFLogxK
U2 - 10.1016/0022-4804(80)90096-7
DO - 10.1016/0022-4804(80)90096-7
M3 - Article
C2 - 7366195
AN - SCOPUS:0018861872
SN - 0022-4804
VL - 28
SP - 356
EP - 366
JO - Journal of Surgical Research
JF - Journal of Surgical Research
IS - 4
ER -