Secreted semaphorins modulate synaptic transmission in the adult hippocampus

Amar Sahay, Chong Hyun Kim, Jehuda P. Sepkuty, Edward Cho, Richard L. Huganir, David D. Ginty, Alex L. Kolodkin

Research output: Contribution to journalArticlepeer-review

114 Scopus citations


Modulation of synaptic activity is critical for neural circuit function and behavior. The semaphorins are a large, phylogenetically conserved protein family with important roles in neural development. However, semaphorin function in the adult brain has yet to be determined. Here, we show that the coreceptors for secreted semaphorins, the neuropilins, are found at synapses and localize to molecular layers of the adult mouse hippocampus and accessory olfactory cortex. Moreover, application of the secreted semaphorin Sema3F to acute hippocampal slices modulates both the frequency and amplitude of miniature EPSCs in granule cells of the dentate gyrus and pyramidal neurons of CA1. Finally, we show that mice lacking Sema3F are prone to seizures. These results suggest a novel role for semaphorins as synaptic modulators and illustrate the diverse repertoire of these guidance cues in both the formation and function of neural circuits.

Original languageEnglish (US)
Pages (from-to)3613-3620
Number of pages8
JournalJournal of Neuroscience
Issue number14
StatePublished - Apr 6 2005


  • AMPA receptors
  • Hippocampus
  • Neuropilins
  • Seizures
  • Semaphorins
  • Synaptic plasticity

ASJC Scopus subject areas

  • Neuroscience(all)


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