TY - JOUR
T1 - Secondhand smoke is an important modifiable risk factor in sickle cell disease
T2 - A review of the current literature and areas for future research
AU - Sadreameli, S. Christy
AU - Kopp, Benjamin T.
AU - Creary, Susan E.
AU - Eakin, Michelle N.
AU - McGrath-Morrow, Sharon
AU - Strouse, John J.
N1 - Publisher Copyright:
© 2016 by the authors; licensee MDPI, Basel, Switzerland.
PY - 2016/11/12
Y1 - 2016/11/12
N2 - Sickle cell disease (SCD) is an autosomal recessive hemoglobinopathy that causes significant morbidity and mortality related to chronic hemolytic anemia, vaso-occlusion, and resultant end-organ damage. Tobacco smoke exposure (TSE) through secondhand smoke exposure in people with SCD of all ages and through primary smoking in adolescents and adults is associated with significantly increased morbidity, with increased rates of emergency department visits and hospitalizations for painful vaso-occlusive crises and acute chest syndrome (ACS). Secondhand smoke is also associated with pulmonary function abnormalities in children with SCD who are already at risk for pulmonary function abnormalities on the basis of SCD. TSE is emerging as one of the few modifiable risk factors of SCD. This review discusses the current state of the evidence with respect to TSE and SCD morbidity, discusses potential mechanisms, and highlights current gaps in the evidence and future research directions.
AB - Sickle cell disease (SCD) is an autosomal recessive hemoglobinopathy that causes significant morbidity and mortality related to chronic hemolytic anemia, vaso-occlusion, and resultant end-organ damage. Tobacco smoke exposure (TSE) through secondhand smoke exposure in people with SCD of all ages and through primary smoking in adolescents and adults is associated with significantly increased morbidity, with increased rates of emergency department visits and hospitalizations for painful vaso-occlusive crises and acute chest syndrome (ACS). Secondhand smoke is also associated with pulmonary function abnormalities in children with SCD who are already at risk for pulmonary function abnormalities on the basis of SCD. TSE is emerging as one of the few modifiable risk factors of SCD. This review discusses the current state of the evidence with respect to TSE and SCD morbidity, discusses potential mechanisms, and highlights current gaps in the evidence and future research directions.
KW - Environmental tobacco smoke
KW - Pulmonary function tests
KW - Secondhand smoke
KW - Sickle cell disease
KW - Tobacco
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U2 - 10.3390/ijerph13111131
DO - 10.3390/ijerph13111131
M3 - Review article
C2 - 27845754
AN - SCOPUS:84995640038
SN - 1661-7827
VL - 13
JO - International journal of environmental research and public health
JF - International journal of environmental research and public health
IS - 11
M1 - 1131
ER -