Secondary malignant giant-cell tumor of bone. Clinicopathological assessment of nineteen patients

M. G. Rock, F. H. Sim, K. K. Unni, G. A. Witrak, F. J. Frassica, M. F. Schray, J. W. Beabout, D. C. Dahlin

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119 Scopus citations


Twenty-six patients who had a malignant giant-cell tumor of bone - a sarcoma either juxtaposed to a zone of typical benign giant-cell tumor or occurring at the site of a previously documented benign giant-cell tumor - have been seen at the Mayo Clinic. Of the twenty-six tumors, nineteen were secondary to a previous attempt at local control of a benign giant-cell tumor. All but one of these nineteen patients with a secondary tumor had received therapeutic irradiation four to thirty-nine years earlier. The nature and duration of the symptoms and the sites of predilection of the malignant giant-cell tumors were the same as for benign giant-cell tumor. Fibrosarcoma occurred three times as frequently as osteosarcoma. The best results of treatment of the secondary sarcoma were obtained with early ablation.

Original languageEnglish (US)
Pages (from-to)1073-1079
Number of pages7
JournalJournal of Bone and Joint Surgery - Series A
Issue number7
StatePublished - Jan 1 1986

ASJC Scopus subject areas

  • Surgery
  • Orthopedics and Sports Medicine


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